Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN11 | Q06124 | 1/20 | 0.47 |
| ▸ | MAP3K11 | Q16584 | 3/20 | 0.42 |
| ▸ | MAP3K9 | P80192 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | TDO2 | P48775 | 1/20 | 0.39 |
| ▸ | IDO2 | Q6ZQW0 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA4 | P22748 | 1/20 | 0.38 |
| ▸ | CA5A | P35218 | 1/20 | 0.38 |
| ▸ | CA7 | P43166 | 1/20 | 0.38 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12067531 | 0.86 | PTPN11 (0.45) | PTPN11MAP3K11TBK1TP53MAPT | |
| SCHEMBL7515012 | 0.86 | MAP3K11 (0.55) | PTPN11MAP3K11MAP3K9MAPK1TBK1 | |
| SCHEMBL22336909 | 0.83 | MAP3K11 (0.45) | MAP3K11MAP3K9MAPK1TBK1TP53 | |
| SCHEMBL15557744 | 0.83 | RET (0.42) | PTPN11MAPK1ADORA2AMEN1KMT2A | |
| SCHEMBL15556013 | 0.82 | MAPK1 (0.44) | PTPN11MAPK1TP53MAPTADORA2A | |
| SCHEMBL31396541 | 0.81 | PTPN11 (0.47) | PTPN11MAP3K11MAP3K9TP53MAPT | |
| SCHEMBL17273313 | 0.80 | MEN1 (0.46) | PTPN11MAPK1TP53MAPTMEN1 | |
| SCHEMBL18860612 | 0.80 | MAPK1 (0.67) | MAPK1ADORA2AMEN1KMT2AGPR119 | |
| SCHEMBL15557891 | 0.79 | MEN1 (0.45) | PTPN11MAPK1TP53MAPTMEN1 | |
| SCHEMBL17273434 | 0.78 | RET (0.44) | PTPN11MEN1KMT2AGPR119ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020163598-A1 | IMMUNOPHILIN-DEPENDENT INHIBITORS AND USES THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2020-08-13 | — | — | WO | disclosed |