SCHEMBL223256

SCHEMBL223256

C[C@@H]1CC[C@H]([C@@H](O)C(F)(F)F)N1c1ccc(C#N)c(Cl)c1

nearest known ligand 0.65

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
AR P10275 6/20 0.50
NR3C1 P04150 1/20 0.50
PGR P06401 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL222281 1.00 AR (0.50) ARNR3C1PGR
SCHEMBL18950211 1.00 AR (0.50) ARNR3C1PGR
SCHEMBL223257 1.00 AR (0.50) ARNR3C1PGR
SCHEMBL20702200 1.00 AR (0.50) ARNR3C1PGR
SCHEMBL22667720 1.00 AR (0.50) ARNR3C1PGR
SCHEMBL220795 1.00 AR (0.50) ARNR3C1PGR
SCHEMBL14837459 1.00 AR (0.50) ARNR3C1PGR
SCHEMBL19976367 0.87 AR (0.53) AR
SCHEMBL223356 0.87 AR (0.51) ARNR3C1PGR
SCHEMBL18950176 0.86 AR (0.64) ARNR3C1PGR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 46 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10730831-B2 Selective androgen receptor modulators (SARMs) and uses thereof LIGAND PHARMACEUTICALS INCORPORATED (US) 2020-08-04 US claimed
US-20190040006-A1 SELECTIVE ANDROGEN RECEPTOR MODULATORS (SARMS) AND USES THEREOF CITIBANK, N.A., AS ADMINISTRATIVE AGENT 2019-02-07 US claimed
US-10106500-B2 Selective androgen receptor modulators (SARMs) and uses thereof LIGAND PHARMACEUTICALS INCORPORATED (US) 2018-10-23 US claimed
US-20170247325-A1 SELECTIVE ANDROGEN RECEPTOR MODULATORS (SARMS) AND USES THEREOF CITIBANK, N.A., AS ADMINISTRATIVE AGENT 2017-08-31 US claimed
US-9675583-B2 Selective androgen receptor modulators (SARMS) and uses thereof LIGAND PHARMACEUTICALS INCORPORATED (US) 2017-06-13 US claimed
US-20160038461-A1 SELECTIVE ANDROGEN RECEPTOR MODULATORS (SARMS) AND USES THEREOF CITIBANK, N.A., AS ADMINISTRATIVE AGENT 2016-02-11 US claimed
US-9139520-B2 Selective androgen receptor modulators (SARMs) and uses thereof LIGAND PHARMACEUTICALS INCORPORATED (US) 2015-09-22 US claimed
US-20140350065-A1 SELECTIVE ANDROGEN RECEPTOR MODULATORS (SARMS) AND USES THEREOF LIGAND PHARMACEUTICALS INCORPORATED (US) 2014-11-27 US claimed
US-8748633-B2 Selective androgen receptor modulators (SARMs) and uses thereof LIGAND PHARMACEUTICALS INCORPORATED (US) 2014-06-10 US claimed
EP-2222636-B1 SELECTIVE ANDROGEN RECEPTOR MODULATORS (SARMS) AND USES THEREOF LIGAND PHARM INC (US) 2013-04-10 EP claimed
US-8354446-B2 Selective androgen receptor modulators (SARMs) and uses thereof LIGAND PHARMACEUTICALS INCORPORATED (US) 2013-01-15 US claimed
US-20120004220-A9 SELECTIVE ANDROGEN RECEPTOR MODULATORS (SARMS) AND USES THEREOF CITIBANK, N.A., AS ADMINISTRATIVE AGENT 2012-01-05 US claimed
US-20100256129-A1 SELECTIVE ANDROGEN RECEPTOR MODULATORS (SARMS) AND USES THEREOF LIGAND PHARMACEUTICALS INCORPORATED 2010-10-07 US claimed
US-11358931-B2 Selective androgen receptor modulators (SARMs) and uses thereof LIGAND PHARMACEUTICALS INCORPORATED (US) 2022-06-14 US disclosed
US-20200361866-A1 SELECTIVE ANDROGEN RECEPTOR MODULATORS (SARMS) AND USES THEREOF CITIBANK, N.A., AS ADMINISTRATIVE AGENT 2020-11-19 US disclosed
US-10730831-B2 Selective androgen receptor modulators (SARMs) and uses thereof LIGAND PHARMACEUTICALS INCORPORATED (US) 2020-08-04 US disclosed
US-20100256129-A1 SELECTIVE ANDROGEN RECEPTOR MODULATORS (SARMS) AND USES THEREOF LIGAND PHARMACEUTICALS INCORPORATED 2010-10-07 US disclosed
US-20100256129-A1 SELECTIVE ANDROGEN RECEPTOR MODULATORS (SARMS) AND USES THEREOF LIGAND PHARMACEUTICALS INCORPORATED 2010-10-07 US disclosed
WO-2009082437-A9 SELECTIVE ANDROGEN RECEPTOR MODULATORS (SARMS) AND USES THEREOF LIGAND PHARMACEUTICALS INCORPORATED (US) 2010-08-12 WO disclosed
WO-2009082437-A2 SELECTIVE ANDROGEN RECEPTOR MODULATORS (SARMS) AND USES THEREOF LIGAND PHARMACEUTICALS INCORPORATED (US) 2009-07-02 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200361866-A1 SELECTIVE ANDROGEN RECEPTOR MODULATORS (SARMS) AND USES THEREOF AR, NR5A1, SHBG AR 1/4885NR3C1 26/4885PGR 92/4885
US-20100256129-A1 SELECTIVE ANDROGEN RECEPTOR MODULATORS (SARMS) AND USES THEREOF AR, NR5A1, SHBG AR 1/4885NR3C1 31/4885PGR 97/4885
US-11358931-B2 Selective androgen receptor modulators (SARMs) and uses thereof AR, NR5A1, SHBG AR 1/4885NR3C1 31/4885PGR 82/4885
US-20170247325-A1 SELECTIVE ANDROGEN RECEPTOR MODULATORS (SARMS) AND USES THEREOF AR, NR5A1, SHBG AR 1/4885NR3C1 26/4885PGR 92/4885
US-10106500-B2 Selective androgen receptor modulators (SARMs) and uses thereof AR, NR5A1, SHBG AR 1/4885NR3C1 31/4885PGR 82/4885
US-20160038461-A1 SELECTIVE ANDROGEN RECEPTOR MODULATORS (SARMS) AND USES THEREOF AR, NR5A1, SHBG AR 1/4885NR3C1 26/4885PGR 92/4885
US-20190040006-A1 SELECTIVE ANDROGEN RECEPTOR MODULATORS (SARMS) AND USES THEREOF AR, NR5A1, SHBG AR 1/4885NR3C1 26/4885PGR 92/4885
US-20140350065-A1 SELECTIVE ANDROGEN RECEPTOR MODULATORS (SARMS) AND USES THEREOF AR, NR5A1, SHBG AR 1/4885NR3C1 26/4885PGR 92/4885
US-10730831-B2 Selective androgen receptor modulators (SARMs) and uses thereof AR, NR5A1, SHBG AR 1/4885NR3C1 31/4885PGR 82/4885
US-20120004220-A9 SELECTIVE ANDROGEN RECEPTOR MODULATORS (SARMS) AND USES THEREOF AR, NR5A1, SHBG AR 1/4885NR3C1 31/4885PGR 97/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.