Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAOX | Q6QHF9 | 2/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 10/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.33 |
| ▸ | CHRNG | P07510 | 1/20 | 0.33 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.33 |
| ▸ | CHRND | Q07001 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22326266 | 0.98 | PAOX (0.41) | PAOXEPHX2CYP2C19GAA | |
| SCHEMBL25369676 | 0.98 | PAOX (0.39) | PAOXEPHX2CYP2C19GAACHRNA1 | |
| SCHEMBL28453694 | 0.94 | TSHR (0.36) | PAOXCHRNA1CHRNGCHRNB1CHRND | |
| SCHEMBL12080215 | 0.94 | TSHR (0.36) | PAOXCHRNA1CHRNGCHRNB1CHRND | |
| SCHEMBL20819275 | 0.92 | TSHR (0.36) | PAOXGAACHRNA1CHRNGCHRNB1 | |
| SCHEMBL21069308 | 0.91 | PAOX (0.50) | PAOXEPHX2CYP2C19ALDH1A1 | |
| SCHEMBL21069585 | 0.91 | PAOX (0.50) | PAOXEPHX2CYP2C19ALDH1A1 | |
| SCHEMBL22326140 | 0.89 | PAOX (0.52) | PAOXCYP2C19GAAALDH1A1 | |
| SCHEMBL21071023 | 0.89 | PAOX (0.52) | PAOXCYP2C19GAAALDH1A1 | |
| SCHEMBL21806080 | 0.86 | PAOX (0.39) | PAOXCHRNA1CHRNGCHRNB1CHRND |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020162725-A1 | TARGET PROTEIN EED DEGRADATION-INDUCING DEGRADUCER, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING DISEASES RELATED TO EED, EZH2, OR PRC2, COMPRISING SAME AS ACTIVE INGREDIENT | 한국화학연구원 | 2020-08-13 | — | — | WO | disclosed |