Sugi Predict

Sugi Predict / Compounds / SCHEMBL22326291

SCHEMBL22326291

SCHEMBL22326291

Cc1ccc(S(=O)(=O)OCCOCCOCCCC(C)(C)C)cc1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 5/20 0.42
▸ CA12 O43570 2/20 0.41
▸ CA1 P00915 2/20 0.41
▸ CA9 Q16790 2/20 0.41
▸ CYP3A4 P08684 2/20 0.38
▸ CYP2C19 P33261 2/20 0.38
▸ CYP2C9 P11712 1/20 0.38
▸ MEN1 O00255 1/20 0.37
▸ KMT2A Q03164 1/20 0.37
▸ STAT3 P40763 1/20 0.36
▸ CYP2D6 P10635 2/20 0.36
▸ CYP1A2 P05177 1/20 0.36
▸ PSMD10 O75832 1/20 0.35
▸ GAA P10253 1/20 0.35
▸ CYP24A1 Q07973 1/20 0.35
▸ G6PD P11413 1/20 0.35
▸ HRH3 Q9Y5N1 1/20 0.35
▸ HTR6 P50406 1/20 0.34
▸ VDR P11473 1/20 0.34
▸ CA2 P00918 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17971061 0.91 ALDH1A1 (0.44) ALDH1A1CA12CA1CA9CYP3A4
SCHEMBL28341552 0.91 ALDH1A1 (0.44) ALDH1A1CA12CA1CA9CYP3A4
SCHEMBL25976232 0.91 ALDH1A1 (0.44) ALDH1A1CA12CA1CA9CYP3A4
SCHEMBL28880308 0.91 ALDH1A1 (0.44) ALDH1A1CA12CA1CA9CYP3A4
SCHEMBL19069752 0.91 ALDH1A1 (0.42) ALDH1A1CA12CA1CA9CYP3A4
SCHEMBL28912198 0.86 ALDH1A1 (0.41) ALDH1A1CA12CA1CA9CYP3A4
SCHEMBL278859 0.86 ALDH1A1 (0.47) ALDH1A1CA12CA1CA9CYP3A4
SCHEMBL478342 0.86 ALDH1A1 (0.53) ALDH1A1CA12CA1CA9CYP3A4
SCHEMBL18613994 0.86 ALDH1A1 (0.53) ALDH1A1CA12CA1CA9CYP3A4
SCHEMBL18644929 0.86 ALDH1A1 (0.53) ALDH1A1CA12CA1CA9CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220105188-A1 TARGET PROTEIN EED DEGRADATION-INDUCING DEGRADUCER, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING DISEASES RELATED TO EED, EZH2, OR PRC2, COMPRISING SAME AS ACTIVE INGREDIENT KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) 2022-04-07 — — US disclosed
EP-3922632-A1 TARGET PROTEIN EED DEGRADATION-INDUCING DEGRADUCER, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING DISEASES RELATED TO EED, EZH2, OR PRC2, COMPRISING SAME AS ACTIVE INGREDIENT Korea Research Institute of Chemical Technology (KR) 2021-12-15 — — EP disclosed
WO-2020162725-A1 TARGET PROTEIN EED DEGRADATION-INDUCING DEGRADUCER, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING DISEASES RELATED TO EED, EZH2, OR PRC2, COMPRISING SAME AS ACTIVE INGREDIENT 한국화학연구원 2020-08-13 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220105188-A1 TARGET PROTEIN EED DEGRADATION-INDUCING DEGRADUCER, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING DISEASES RELATED TO EED, EZH2, OR PRC2, COMPRISING SAME AS ACTIVE INGREDIENT EED, VHL, CUL1 ALDH1A1 1587/4885CA12 3934/4885CA1 2108/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.