Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYMS | P04818 | 11/20 | 0.41 |
| ▸ | PDE2A | O00408 | 2/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
| ▸ | MTOR | P42345 | 1/20 | 0.35 |
| ▸ | RICTOR | Q6R327 | 1/20 | 0.35 |
| ▸ | RPTOR | Q8N122 | 1/20 | 0.35 |
| ▸ | MAPKAP1 | Q9BPZ7 | 1/20 | 0.35 |
| ▸ | MLST8 | Q9BVC4 | 1/20 | 0.35 |
| ▸ | XDH | P47989 | 1/20 | 0.34 |
| ▸ | DHFR | P00374 | 2/20 | 0.34 |
| ▸ | HPRT1 | P00492 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18520027 | 0.90 | TYMS (0.42) | TYMSPDE2APIK3CAMTORRICTOR | |
| SCHEMBL24971314 | 0.83 | DHFR (0.39) | TYMSPDE2APIK3CAMTORRICTOR | |
| SCHEMBL18520802 | 0.79 | TYMS (0.44) | TYMSXDHDHFR | |
| SCHEMBL25809396 | 0.78 | PARP1 (0.39) | MTORRICTORRPTORMAPKAP1MLST8 | |
| SCHEMBL21137421 | 0.77 | TYMS (0.46) | TYMSXDH | |
| SCHEMBL23679500 | 0.76 | TYMS (0.44) | TYMSXDH | |
| SCHEMBL23476717 | 0.75 | TYMS (0.42) | TYMSPDE2AXDHDHFR | |
| SCHEMBL20326889 | 0.75 | TYMS (0.42) | TYMSPDE2ADHFRMEN1KMT2A | |
| SCHEMBL24236939 | 0.75 | TYMS (0.42) | TYMSXDHDHFR | |
| SCHEMBL21127781 | 0.74 | TYMS (0.40) | TYMSPDE2APIK3CAMTORRICTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10738074-B2 | Cyclic di-nucleotide compounds as STING agonists | MERCK SHARP & DOHME CORP. (US) | 2020-08-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10738074-B2 | Cyclic di-nucleotide compounds as STING agonists | STING1, CGAS, IFNAR1 | TYMS 1755/4885PDE2A 168/4885PIK3CA 2328/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.