Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHA2 | P29317 | 2/20 | 0.84 |
| ▸ | EGFR | P00533 | 2/20 | 0.63 |
| ▸ | NFKBIA | P25963 | 1/20 | 0.54 |
| ▸ | AKT1 | P31749 | 1/20 | 0.54 |
| ▸ | PTGER2 | P43116 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | USP19 | O94966 | 1/20 | 0.31 |
| ▸ | CNR1 | P21554 | 1/20 | 0.30 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.30 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.30 |
| ▸ | F2R | P25116 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22328117 | 0.91 | EPHA2 (1.00) | EPHA2EGFRNFKBIAAKT1PTGER2 | |
| SCHEMBL19003322 | 0.77 | EPHA2 (0.75) | EPHA2EGFRNFKBIAAKT1PTGER2 | |
| SCHEMBL19003321 | 0.77 | EPHA2 (0.75) | EPHA2EGFRNFKBIAAKT1PTGER2 | |
| SCHEMBL22328134 | 0.72 | EPHA2 (1.00) | EPHA2EGFRNFKBIAAKT1PTGER2 | |
| SCHEMBL24996897 | 0.71 | EGFR (0.87) | EPHA2EGFRNFKBIAAKT1PTGER2 | |
| SCHEMBL22730944 | 0.71 | EPHA2 (0.65) | EPHA2EGFRNFKBIAAKT1PTGER2 | |
| SCHEMBL24996893 | 0.71 | EGFR (0.86) | EPHA2EGFRNFKBIAAKT1PTGER2 | |
| SCHEMBL19003382 | 0.70 | EPHA2 (0.66) | EPHA2EGFRNFKBIAAKT1PTGER2 | |
| SCHEMBL19003412 | 0.67 | EPHA2 (0.62) | EPHA2EGFRNFKBIAAKT1PTGER2 | |
| SCHEMBL19003318 | 0.67 | EPHA2 (0.62) | EPHA2EGFRNFKBIAAKT1PTGER2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10738082-B2 | One-bead-two-compound macrocyclic library and methods of preparation and use | UNIVERSITY OF SOUTH FLORIDA (US) | 2020-08-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10738082-B2 | One-bead-two-compound macrocyclic library and methods of preparation and use | EPHA2, EPHA1, EPHB2 | EPHA2 1/4885EGFR 26/4885NFKBIA 3054/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.