Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 2/20 | 0.47 |
| ▸ | CYP1A1 | P04798 | 3/20 | 0.41 |
| ▸ | CYP1B1 | Q16678 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 5/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | PTP4A3 | O75365 | 1/20 | 0.40 |
| ▸ | PTP4A2 | Q12974 | 1/20 | 0.40 |
| ▸ | PTP4A1 | Q93096 | 1/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24369567 | 0.87 | CYP1A1 (0.41) | APPCYP1A1CYP1B1ALDH1A1MAPT | |
| SCHEMBL24368533 | 0.86 | CYP1A1 (0.44) | APPCYP1A1CYP1B1ALDH1A1MAPT | |
| SCHEMBL24368534 | 0.86 | CYP1A1 (0.44) | APPCYP1A1CYP1B1ALDH1A1MAPT | |
| SCHEMBL24368570 | 0.86 | CYP1A1 (0.44) | APPCYP1A1CYP1B1ALDH1A1MAPT | |
| SCHEMBL24368540 | 0.86 | CYP1A1 (0.44) | APPCYP1A1CYP1B1ALDH1A1MAPT | |
| SCHEMBL24369566 | 0.86 | CYP1A1 (0.44) | APPCYP1A1CYP1B1ALDH1A1MAPT | |
| SCHEMBL2234404 | 0.85 | CYP1A1 (0.47) | APPCYP1A1CYP1B1MAPTCYP1A2 | |
| SCHEMBL12345731 | 0.84 | JAK2 (0.40) | APPALDH1A1KDM4ERAB9ASMN1; SMN2 | |
| SCHEMBL11966157 | 0.84 | APP (0.46) | APPCYP1A1CYP1B1ALDH1A1MAPT | |
| SCHEMBL23337582 | 0.82 | CYP1A1 (0.51) | CYP1A1CYP1B1ALDH1A1MAPTCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2361915-B1 | NOVEL HETEROCYCLIC COMPOUND AND USE THEREOF | NIPPON KAYAKU KK (JP) | 2015-01-28 | — | — | EP | disclosed |
| EP-2361915-B1 | NOVEL HETEROCYCLIC COMPOUND AND USE THEREOF | NIPPON KAYAKU KK (JP) | 2015-01-28 | — | — | EP | disclosed |
| US-8313671-B2 | Heterocyclic compound and use thereof | HIROSHIMA UNIVERSITY (JP) | 2012-11-20 | — | — | US | disclosed |
| US-8313671-B2 | Heterocyclic compound and use thereof | HIROSHIMA UNIVERSITY (JP) | 2012-11-20 | — | — | US | disclosed |
| US-8313671-B2 | Heterocyclic compound and use thereof | HIROSHIMA UNIVERSITY (JP) | 2012-11-20 | — | — | US | disclosed |
| EP-2361915-A1 | NOVEL HETEROCYCLIC COMPOUND AND USE THEREOF | Hiroshima University (JP) | 2011-08-31 | — | — | EP | disclosed |
| US-20110204295-A1 | Novel Heterocyclic Compound And Use Thereof | HIROSHIMA UNIVERSITY (JP) | 2011-08-25 | — | — | US | disclosed |
| US-20110204295-A1 | Novel Heterocyclic Compound And Use Thereof | HIROSHIMA UNIVERSITY (JP) | 2011-08-25 | — | — | US | disclosed |
| US-20110204295-A1 | Novel Heterocyclic Compound And Use Thereof | HIROSHIMA UNIVERSITY (JP) | 2011-08-25 | — | — | US | disclosed |
| WO-2010058833-A1 | NOVEL HETEROCYCLIC COMPOUND AND USE THEREOF | 国立大学法人広島大学 (JP) | 2010-05-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110204295-A1 | Novel Heterocyclic Compound And Use Thereof | SCLY, C9, C1S | APP 2561/4885CYP1A1 119/4885CYP1B1 199/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.