Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.45 |
| ▸ | FLT4 | P35916 | 1/20 | 0.45 |
| ▸ | GSK3B | P49841 | 1/20 | 0.45 |
| ▸ | RARB | P10826 | 1/20 | 0.45 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.45 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | HPGD | P15428 | 4/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | XBP1 | P17861 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18313186 | 1.00 | KMT2A (0.53) | KMT2AMAPTTHRBEPHA2FLT4 | |
| SCHEMBL21440596 | 1.00 | KMT2A (0.53) | KMT2AMAPTTHRBEPHA2FLT4 | |
| SCHEMBL18313296 | 0.93 | KMT2A (0.51) | KMT2AMAPTTHRBEPHA2FLT4 | |
| SCHEMBL18312803 | 0.89 | MAPT (0.49) | KMT2AMAPTTHRBEPHA2FLT4 | |
| SCHEMBL21440681 | 0.87 | KMT2A (0.66) | KMT2AEPHA2FLT4GSK3BRARB | |
| SCHEMBL18313209 | 0.87 | KMT2A (0.66) | KMT2AEPHA2FLT4GSK3BRARB | |
| SCHEMBL18313674 | 0.87 | KMT2A (0.66) | KMT2AEPHA2FLT4GSK3BRARB | |
| SCHEMBL21440598 | 0.86 | ALDH1A1 (0.56) | KMT2AMAPTTHRBEPHA2FLT4 | |
| SCHEMBL18313500 | 0.86 | KDM4E (0.45) | KMT2AMAPTTHRBEPHA2FLT4 | |
| SCHEMBL18313672 | 0.85 | MAPT (0.48) | KMT2AMAPTTHRBEPHA2FLT4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3692991-A1 | POSITIVE ALLOSTERIC MODULATORS OF THE MUSCARINIC M2 RECEPTOR | Bayer Pharma Aktiengesellschaft (DE) | 2020-08-12 | — | — | EP | disclosed |