SCHEMBL2233414

SCHEMBL2233414

COC(=O)NN(C(=O)Oc1ccc(C(F)(F)F)cc1)c1ccccc1OC

nearest known ligand 0.53

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
LIPE Q05469 8/20 0.53
MAPT P10636 2/20 0.41
NPSR1 Q6W5P4 2/20 0.41
CETP P11597 1/20 0.38
CYP11B1 P15538 1/20 0.38
CYP11B2 P19099 1/20 0.38
KIF11 P52732 1/20 0.37
MEN1 O00255 1/20 0.36
RAB9A P51151 1/20 0.36
KMT2A Q03164 1/20 0.36
CYP1A1 P04798 2/20 0.36
CYP1B1 Q16678 2/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2235392 0.86 POLB (0.41) LIPEMAPTMEN1RAB9AKMT2A
SCHEMBL2232497 0.85 MAPT (0.41) LIPEMAPTNPSR1MEN1RAB9A
SCHEMBL2236294 0.84 ATM (0.47) LIPEMAPTNPSR1CYP11B1CYP11B2
SCHEMBL2232860 0.82 ATM (0.44) LIPEMAPTKMT2A
SCHEMBL2233290 0.81 ALDH1A1 (0.50) MAPTMEN1KMT2A
SCHEMBL2235417 0.80 KMT2A (0.43) MAPTMEN1KMT2A
SCHEMBL2237995 0.76 HPGD (0.41) MAPTNPSR1MEN1RAB9AKMT2A
SCHEMBL2234563 0.75 KDM4E (0.43) MAPTNPSR1MEN1RAB9AKMT2A
SCHEMBL2236089 0.74 ALDH1A1 (0.43) MAPTNPSR1MEN1KMT2A
SCHEMBL2232541 0.74 TACR3 (0.43) MAPTNPSR1MEN1RAB9AKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8299264-B2 Method for producing oxadiazolinone compound and intermediate thereof SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2012-10-30 US disclosed
US-20110207936-A1 METHOD FOR PRODUCING OXADIAZOLINONE COMPOUND AND INTERMEDIATE THEREOF SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2011-08-25 US disclosed
EP-2357167-A1 METHOD FOR PRODUCING OXADIAZOLINONE COMPOUND AND INTERMEDIATE THEREOF Sumitomo Chemical Company, Limited (JP) 2011-08-17 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110207936-A1 METHOD FOR PRODUCING OXADIAZOLINONE COMPOUND AND INTERMEDIATE THEREOF AHR, CYP1B1, AR LIPE 4747/4885MAPT 3838/4885NPSR1 2907/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.