Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 7/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | XIAP | P98170 | 3/20 | 0.39 |
| ▸ | MME | P08473 | 3/20 | 0.38 |
| ▸ | ACE | P12821 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | CRHBP | P24387 | 1/20 | 0.37 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2235527 | 0.91 | MME (0.40) | RIPK1NPC1LMNATP53HPGD | |
| SCHEMBL2235118 | 0.87 | NPC1 (0.37) | RIPK1NPC1LMNATP53HPGD | |
| SCHEMBL2236134 | 0.85 | RIPK1 (0.46) | RIPK1 | |
| SCHEMBL2236141 | 0.85 | RIPK1 (0.46) | RIPK1 | |
| SCHEMBL2236369 | 0.84 | KMT2A (0.44) | RIPK1XIAPMMEACEALDH1A1 | |
| SCHEMBL2237725 | 0.82 | SCN9A (0.41) | RIPK1NPC1LMNATP53HPGD | |
| SCHEMBL14228458 | 0.75 | RIPK1 (0.44) | RIPK1LMNASMN1; SMN2NPSR1XIAP | |
| SCHEMBL3913698 | 0.74 | RIPK1 (0.64) | RIPK1XIAPMMEACE | |
| SCHEMBL4703212 | 0.73 | RIPK1 (0.48) | RIPK1NPC1LMNATP53HPGD | |
| SCHEMBL4704022 | 0.72 | RIPK1 (0.46) | RIPK1LMNASMN1; SMN2XIAPMME |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7994161-B2 | Derivatives of 2-alkoxy-3,4,5-trihydroxy-alkyl amides, preparation and use thereof, and compositions containing the same | SANOFI-AVENTIS (FR) | 2011-08-09 | — | — | US | disclosed |