Sugi Predict

Sugi Predict / Compounds / SCHEMBL22337173

SCHEMBL22337173

SCHEMBL22337173

CC(C)C(=O)Nc1nc2c(ncn2[C@@H]2O[C@H](CO)C(N)C2O[Si](C)(C)C(C)(C)C)c(=O)[nH]1

nearest known ligand 0.59

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
▸ KDM4E B2RXH2 1/20 0.54
▸ TAS1R3 Q7RTX0 2/20 0.46
▸ TAS1R1 Q7RTX1 2/20 0.46
▸ HPGD P15428 2/20 0.42
▸ ALDH1A1 P00352 1/20 0.40
▸ MEN1 O00255 1/20 0.39
▸ KMT2A Q03164 1/20 0.39
▸ HINT1 P49773 3/20 0.38
▸ STING1 Q86WV6 1/20 0.38
▸ IMPDH2 P12268 1/20 0.38
▸ ADORA2A P29274 2/20 0.37
▸ ADORA2B P29275 2/20 0.37
▸ POLA1 P09884 1/20 0.37
▸ ADORA3 P0DMS8 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20654966 1.00 KDM4E (0.54) KDM4ETAS1R3TAS1R1HPGDALDH1A1
SCHEMBL26808246 1.00 KDM4E (0.54) KDM4ETAS1R3TAS1R1HPGDALDH1A1
SCHEMBL22337233 1.00 KDM4E (0.54) KDM4ETAS1R3TAS1R1HPGDALDH1A1
SCHEMBL26808292 1.00 KDM4E (0.54) KDM4ETAS1R3TAS1R1HPGDALDH1A1
SCHEMBL19127787 1.00 KDM4E (0.54) KDM4ETAS1R3TAS1R1HPGDALDH1A1
SCHEMBL19128037 1.00 KDM4E (0.54) KDM4ETAS1R3TAS1R1HPGDALDH1A1
SCHEMBL29870290 1.00 KDM4E (0.54) KDM4ETAS1R3TAS1R1HPGDALDH1A1
SCHEMBL30173456 0.98 KDM4E (0.53) KDM4ETAS1R3TAS1R1HPGDALDH1A1
SCHEMBL20655066 0.94 KDM4E (0.49) KDM4ETAS1R3TAS1R1HPGDALDH1A1
SCHEMBL26808496 0.94 KDM4E (0.56) KDM4ETAS1R3TAS1R1HPGDALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230357306-A1 SYNTHESIS OF 1,2,5-TRI-O-BENZOYL-3-DIBENZYLAMINO-3-DEOXYRIBOSE AS INTERMEDIATE FOR PRODUCING 3'-AMINO-3'-DEOXYADENOSINE AND 3'-AMINO-3'-DEOXYGUANOSINE AND THE PROTECTED DERIVATIVES THEREOF BRISTOL MYERS SQUIBB CO (US) 2023-11-09 — — US disclosed
US-20230073999-A1 POLYNUCLEOTIDE AND PHARMACEUTICAL COMPOSITION NATIONAL UNIVERSITY CORPORATION TOKAI NATIONAL HIGHER EDUCATION AND RESEARCH SYSTEM (JP) 2023-03-09 — — US disclosed
WO-2021132589-A1 POLYNUCLEOTIDE AND MEDICINAL COMPOSITION 国立大学法人東海国立大学機構 2021-07-01 — — WO disclosed
WO-2020163415-A1 SYNTHESIS OF 1,2,5-TRI-0-BENZ0YL-3-DIBENZYLAMIN0-3-DE0XYRIB0SE AS INTERMEDIATE FOR PRODUCING 3'-AMINO-3'-DEOXYADENOSINE AND 3'-AMINO-3'-DEOXYGUANOSINE AND THE PROTECTED DERIVATIVES THEREOF BRISTOL-MYERS SQUIBB COMPANY (US) 2020-08-13 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230357306-A1 SYNTHESIS OF 1,2,5-TRI-O-BENZOYL-3-DIBENZYLAMINO-3-DEOXYRIBOSE AS INTERMEDIATE FOR PRODUCING 3'-AMINO-3'-DEOXYADENOSINE AND 3'-AMINO-3'-DEOXYGUANOSINE AND THE PROTECTED DERIVATIVES THEREOF STING1, CGAS, AMPD3 KDM4E 1990/4885TAS1R3 484/4885TAS1R1 728/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.