Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IMPDH2 known ✓ | P12268 | 1/20 | 0.37 |
| ▸ | ADORA2A known ✓ | P29274 | 2/20 | 0.36 |
| ▸ | ADORA2B known ✓ | P29275 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.45 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HINT1 | P49773 | 3/20 | 0.38 |
| ▸ | STING1 | Q86WV6 | 1/20 | 0.37 |
| ▸ | POLA1 | P09884 | 1/20 | 0.36 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20654966 | 0.98 | KDM4E (0.54) | KDM4ETAS1R3TAS1R1HPGDMEN1 | |
| SCHEMBL29870290 | 0.98 | KDM4E (0.54) | KDM4ETAS1R3TAS1R1HPGDMEN1 | |
| SCHEMBL26808246 | 0.98 | KDM4E (0.54) | KDM4ETAS1R3TAS1R1HPGDMEN1 | |
| SCHEMBL19127787 | 0.98 | KDM4E (0.54) | KDM4ETAS1R3TAS1R1HPGDMEN1 | |
| SCHEMBL19128037 | 0.98 | KDM4E (0.54) | KDM4ETAS1R3TAS1R1HPGDMEN1 | |
| SCHEMBL26808292 | 0.98 | KDM4E (0.54) | KDM4ETAS1R3TAS1R1HPGDMEN1 | |
| SCHEMBL22337173 | 0.98 | KDM4E (0.54) | KDM4ETAS1R3TAS1R1HPGDMEN1 | |
| SCHEMBL22337233 | 0.98 | KDM4E (0.54) | KDM4ETAS1R3TAS1R1HPGDMEN1 | |
| SCHEMBL20655066 | 0.92 | KDM4E (0.49) | KDM4ETAS1R3TAS1R1HPGDMEN1 | |
| SCHEMBL26808496 | 0.92 | KDM4E (0.56) | KDM4ETAS1R3TAS1R1HPGDMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023277168-A1 | POLYNUCLEOTIDE AND MEDICINAL COMPOSITION | 協和キリン株式会社 | 2023-01-05 | — | — | WO | disclosed |