Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 1/20 | 0.55 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.51 |
| ▸ | GRM1 | Q13255 | 10/20 | 0.48 |
| ▸ | GRM5 | P41594 | 9/20 | 0.48 |
| ▸ | HTR6 | P50406 | 1/20 | 0.47 |
| ▸ | WNT3A | P56704 | 1/20 | 0.47 |
| ▸ | CDK7 | P50613 | 1/20 | 0.45 |
| ▸ | CDK13 | Q14004 | 1/20 | 0.45 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.45 |
| ▸ | KIT | P10721 | 1/20 | 0.44 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.43 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.43 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17876418 | 0.85 | NAMPT (0.57) | NAMPTPDK4GRM1GRM5HTR6 | |
| SCHEMBL12440413 | 0.84 | NAMPT (0.56) | NAMPTPDK4GRM1GRM5HTR6 | |
| SCHEMBL22325023 | 0.84 | NAMPT (0.56) | NAMPTPDK4GRM1GRM5HTR6 | |
| SCHEMBL14790770 | 0.84 | NAMPT (0.56) | NAMPTPDK4GRM1GRM5HTR6 | |
| SCHEMBL21171650 | 0.84 | NAMPT (0.58) | NAMPTPDK4GRM1GRM5HTR6 | |
| SCHEMBL8912847 | 0.83 | NAMPT (0.63) | NAMPTPDK4GRM1GRM5HTR6 | |
| SCHEMBL16492725 | 0.82 | NAMPT (0.54) | NAMPTPDK4GRM1GRM5HTR6 | |
| SCHEMBL17825458 | 0.82 | GPR119 (0.55) | NAMPTPDK4GRM1GRM5HTR6 | |
| SCHEMBL22340251 | 0.82 | GPR119 (0.55) | NAMPTPDK4GRM1GRM5HTR6 | |
| SCHEMBL14990423 | 0.82 | NAMPT (0.57) | NAMPTPDK4GRM1GRM5HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020163689-A1 | 20-HETE FORMATION INHIBITORS | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2020-08-13 | — | — | WO | disclosed |