Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.75 |
| ▸ | GAA | P10253 | 2/20 | 0.75 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.75 |
| ▸ | MAPT | P10636 | 1/20 | 0.75 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.75 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.62 |
| ▸ | MEN1 | O00255 | 4/20 | 0.62 |
| ▸ | RAB9A | P51151 | 3/20 | 0.62 |
| ▸ | NPC1 | O15118 | 1/20 | 0.62 |
| ▸ | CTSD | P07339 | 1/20 | 0.61 |
| ▸ | LMNA | P02545 | 1/20 | 0.60 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.59 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.59 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.59 |
| ▸ | METAP2 | P50579 | 1/20 | 0.58 |
| ▸ | STAT3 | P40763 | 1/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | TP53 | P04637 | 1/20 | 0.58 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12912328 | 0.87 | KCNMA1 (0.71) | TSHRGAAHSD17B10MAPTMAPK1 | |
| SCHEMBL12368122 | 0.87 | KMT2A (0.79) | TSHRGAAHSD17B10MAPTMAPK1 | |
| SCHEMBL11789728 | 0.86 | KCNK3 (0.66) | TSHRGAAHSD17B10MAPTMAPK1 | |
| SCHEMBL5928993 | 0.86 | TSHR (1.00) | TSHRGAAHSD17B10MAPTMAPK1 | |
| SCHEMBL27848838 | 0.86 | KMT2A (0.77) | TSHRGAAHSD17B10MAPTMAPK1 | |
| SCHEMBL1623330 | 0.85 | MAPT (0.73) | TSHRGAAHSD17B10MAPTMAPK1 | |
| SCHEMBL28585692 | 0.83 | TSHR (0.73) | TSHRGAAHSD17B10MAPTMAPK1 | |
| SCHEMBL12368197 | 0.83 | KCNMA1 (0.74) | TSHRGAAHSD17B10MAPTMAPK1 | |
| SCHEMBL7367182 | 0.82 | CHEK1 (0.80) | TSHRHSD17B10KMT2AMEN1RAB9A | |
| SCHEMBL1624054 | 0.82 | KMT2A (0.56) | TSHRGAAHSD17B10MAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020163236-A1 | TREATING LONG QT SYNDROME | THE GENERAL HOSPITAL CORPORATION (US) | 2020-08-13 | — | — | WO | disclosed |