Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA9 | Q16790 | 9/20 | 1.00 |
| ▸ | CA12 | O43570 | 8/20 | 1.00 |
| ▸ | FEN1 | P39748 | 8/20 | 0.66 |
| ▸ | DAO | P14920 | 1/20 | 0.60 |
| ▸ | ERCC1 | P07992 | 4/20 | 0.59 |
| ▸ | ERCC4 | Q92889 | 4/20 | 0.59 |
| ▸ | DNASE1 | P24855 | 2/20 | 0.59 |
| ▸ | RNASEH1 | O60930 | 1/20 | 0.59 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.59 |
| ▸ | CMA1 | P23946 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29933887 | 1.00 | CA9 (1.00) | CA9CA12FEN1DAOERCC1 | |
| SCHEMBL29960129 | 0.79 | FEN1 (1.00) | CA9CA12FEN1DAOERCC1 | |
| SCHEMBL18670385 | 0.79 | FEN1 (1.00) | CA9CA12FEN1DAOERCC1 | |
| SCHEMBL6406738 | 0.79 | CA9 (0.66) | CA9CA12CMA1 | |
| SCHEMBL9919009 | 0.79 | CA9 (0.66) | CA9CA12DAOCMA1 | |
| SCHEMBL22341562 | 0.77 | FEN1 (0.62) | CA9CA12FEN1ERCC1ERCC4 | |
| SCHEMBL11011553 | 0.76 | CA9 (0.61) | CA9CA12CMA1 | |
| SCHEMBL18670498 | 0.76 | FEN1 (1.00) | CA9CA12FEN1ERCC1ERCC4 | |
| SCHEMBL31207287 | 0.76 | CYP1A2 (0.62) | CA9CA12CMA1 | |
| SCHEMBL31393248 | 0.76 | CA9 (0.60) | CA9CA12CMA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111303054-B | 3-acylamino-1, 3-quinazoline-2-ketone compound and preparation method and application thereof | 湖南科技大学 | 2023-04-07 | — | — | CN | disclosed |
| EP-3353154-B1 | 3-HYDROXY-7-(SULFONYL)QUINAZOLINE-2,4(1H,3H)-DIONE AND 3-HYDROXY-PYRIDO[2,3-D]PYRIMIDINE-2,4(1H,3H)-DIONE DERIVATIVES AND RELATED COMPOUNDS AS FLAP-ENDONUCLEASE 1 (FEN-1) INHIBITORS FOR USE IN CANCER THERAPY | LUDWIG INST FOR CANCER RES LTD (CH) | 2020-08-19 | — | — | EP | disclosed |
| CN-111303054-A | 3-acylamino-1, 3-quinazoline-2-ketone compound and preparation method and application thereof | 湖南科技大学 | 2020-06-19 | — | — | CN | disclosed |