Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FEN1 | P39748 | 11/20 | 0.62 |
| ▸ | CA12 | O43570 | 8/20 | 0.62 |
| ▸ | CA9 | Q16790 | 8/20 | 0.62 |
| ▸ | ERCC1 | P07992 | 4/20 | 0.56 |
| ▸ | ERCC4 | Q92889 | 4/20 | 0.56 |
| ▸ | DNASE1 | P24855 | 2/20 | 0.56 |
| ▸ | RNASEH1 | O60930 | 1/20 | 0.56 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29933887 | 0.77 | CA9 (1.00) | FEN1CA12CA9ERCC1ERCC4 | |
| SCHEMBL22341565 | 0.77 | CA9 (1.00) | FEN1CA12CA9ERCC1ERCC4 | |
| SCHEMBL29960129 | 0.77 | FEN1 (1.00) | FEN1CA12CA9ERCC1ERCC4 | |
| SCHEMBL29959916 | 0.73 | FEN1 (1.00) | FEN1CA12CA9ERCC1ERCC4 | |
| SCHEMBL18670498 | 0.73 | FEN1 (1.00) | FEN1CA12CA9ERCC1ERCC4 | |
| SCHEMBL29933774 | 0.72 | FEN1 (1.00) | FEN1CA12CA9ERCC1ERCC4 | |
| SCHEMBL18213773 | 0.70 | GAA (0.42) | — | |
| SCHEMBL24262310 | 0.70 | FEN1 (0.63) | FEN1CA12CA9ERCC1ERCC4 | |
| SCHEMBL29959783 | 0.70 | FEN1 (0.63) | FEN1CA12CA9ERCC1ERCC4 | |
| SCHEMBL18670563 | 0.70 | FEN1 (1.00) | FEN1CA12CA9ERCC1ERCC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3353154-B3 | 3-HYDROXY-7-(SULFONYL)QUINAZOLINE-2,4(1H,3H)-DIONE AND 3-HYDROXY-PYRIDO[2,3-D]PYRIMIDINE-2,4(1H,3H)-DIONE DERIVATIVES AND RELATED COMPOUNDS AS FLAP-ENDONUCLEASE 1 (FEN-1) INHIBITORS FOR USE IN CANCER THERAPY | LUDWIG INST FOR CANCER RES LTD (CH) | 2022-10-19 | — | — | EP | disclosed |
| EP-3353154-B1 | 3-HYDROXY-7-(SULFONYL)QUINAZOLINE-2,4(1H,3H)-DIONE AND 3-HYDROXY-PYRIDO[2,3-D]PYRIMIDINE-2,4(1H,3H)-DIONE DERIVATIVES AND RELATED COMPOUNDS AS FLAP-ENDONUCLEASE 1 (FEN-1) INHIBITORS FOR USE IN CANCER THERAPY | LUDWIG INST FOR CANCER RES LTD (CH) | 2020-08-19 | — | — | EP | disclosed |