Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 18/20 | 0.66 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22323999 | 0.87 | TYK2 (0.73) | TYK2PDE4DKDM4E | |
| SCHEMBL22343290 | 0.86 | TYK2 (0.65) | TYK2PDE4DALDH1A1HPGDHSD17B10 | |
| SCHEMBL22343291 | 0.84 | TYK2 (0.77) | TYK2PDE4D | |
| SCHEMBL20679020 | 0.84 | TYK2 (0.83) | TYK2PDE4D | |
| SCHEMBL21948230 | 0.82 | KDM4E (0.53) | TYK2KDM4ENPC1ALDH1A1HPGD | |
| SCHEMBL22324403 | 0.81 | TYK2 (0.69) | TYK2PDE4D | |
| SCHEMBL21887788 | 0.81 | TYK2 (0.53) | TYK2PDE4DKDM4ENPC1ALDH1A1 | |
| SCHEMBL30349558 | 0.81 | TYK2 (0.61) | TYK2PDE4DKDM4ENPC1ALDH1A1 | |
| SCHEMBL21811191 | 0.81 | TYK2 (0.61) | TYK2PDE4DKDM4ENPC1ALDH1A1 | |
| SCHEMBL20689018 | 0.81 | KDM4E (0.52) | TYK2KDM4ENPC1ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220135567-A1 | TYK2 PSEUDOKINASE LIGANDS | VENTYX BIOSCIENCES, INC. | 2022-05-05 | — | — | US | disclosed |
| WO-2020163778-A1 | TYK2 PSEUDOKINASE LIGANDS | VENTYX BIOSCIENCES, INC. (US) | 2020-08-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220135567-A1 | TYK2 PSEUDOKINASE LIGANDS | TYK2, JAK2, PTK2B | TYK2 1/4885PDE4D 4544/4885KDM4E 2268/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.