Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.67 |
| ▸ | MEN1 | O00255 | 3/20 | 0.67 |
| ▸ | BLM | P54132 | 1/20 | 0.67 |
| ▸ | APP | P05067 | 1/20 | 0.64 |
| ▸ | MAPT | P10636 | 8/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 7/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.62 |
| ▸ | NPSR1 | Q6W5P4 | 5/20 | 0.62 |
| ▸ | RECQL | P46063 | 1/20 | 0.62 |
| ▸ | SOS1 | Q07889 | 3/20 | 0.60 |
| ▸ | LMNA | P02545 | 6/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.59 |
| ▸ | HPGD | P15428 | 3/20 | 0.59 |
| ▸ | USP2 | O75604 | 2/20 | 0.59 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29490079 | 1.00 | KMT2A (0.67) | KMT2AMEN1BLMAPPMAPT | |
| SCHEMBL2587104 | 0.88 | APP (0.76) | KMT2AMEN1APPMAPTMAPK1 | |
| SCHEMBL30455311 | 0.83 | MAPT (0.81) | KMT2AMEN1BLMMAPTMAPK1 | |
| SCHEMBL23747980 | 0.81 | HTT (0.72) | KMT2AMEN1APPMAPTMAPK1 | |
| SCHEMBL30125191 | 0.81 | HTT (0.72) | KMT2AMEN1APPMAPTMAPK1 | |
| SCHEMBL30455471 | 0.80 | MAPT (0.72) | KMT2AMEN1BLMAPPMAPT | |
| SCHEMBL4867976 | 0.79 | APP (0.76) | KMT2AMEN1APPMAPTMAPK1 | |
| SCHEMBL22342962 | 0.78 | CTNNB1 (0.77) | KMT2AMEN1BLMAPPMAPT | |
| SCHEMBL29490089 | 0.78 | CTNNB1 (0.77) | KMT2AMEN1BLMAPPMAPT | |
| SCHEMBL3108468 | 0.78 | APP (0.74) | KMT2AMEN1APPMAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11318137-B2 | Quinazoline compounds as modulators of Ras signaling | VANDERBILT UNIVERSITY (US) | 2022-05-03 | — | — | US | disclosed |
| US-20200253974-A1 | QUINAZOLINE COMPOUNDS AS MODULATORS OF RAS SIGNALING | VANDERBILT UNIVERSITY | 2020-08-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200253974-A1 | QUINAZOLINE COMPOUNDS AS MODULATORS OF RAS SIGNALING | NRAS, KRAS, MAVS | KMT2A 3348/4885MEN1 851/4885BLM 2117/4885 |
| US-11318137-B2 | Quinazoline compounds as modulators of Ras signaling | NRAS, KRAS, MAVS | KMT2A 3348/4885MEN1 851/4885BLM 2117/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.