Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SREBF2 | Q12772 | 1/20 | 0.38 |
| ▸ | AAK1 | Q2M2I8 | 9/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.30 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.30 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.30 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.30 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.30 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.30 |
| ▸ | EGFR | P00533 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL616659 | 1.00 | SREBF2 (0.38) | SREBF2AAK1SMN1; SMN2PSEN1PSEN2 | |
| SCHEMBL614167 | 0.95 | SREBF2 (0.36) | SREBF2MAPT | |
| SCHEMBL616816 | 0.89 | SREBF2 (0.38) | SREBF2AAK1PSEN1PSEN2APH1B | |
| SCHEMBL616966 | 0.85 | SREBF2 (0.40) | SREBF2AAK1PSEN1PSEN2APH1B | |
| SCHEMBL2237564 | 0.84 | SREBF2 (0.39) | SREBF2AAK1 | |
| SCHEMBL615587 | 0.84 | SREBF2 (0.39) | SREBF2AAK1 | |
| SCHEMBL2233338 | 0.83 | SREBF2 (0.40) | SREBF2AAK1 | |
| SCHEMBL616658 | 0.83 | SMN1; SMN2 (0.36) | SREBF2AAK1SMN1; SMN2PSEN1PSEN2 | |
| SCHEMBL2236912 | 0.80 | SREBF2 (0.39) | SREBF2AAK1PSEN1PSEN2APH1B | |
| SCHEMBL613985 | 0.80 | SREBF2 (0.36) | SREBF2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2534154-A1 | MACROCYCLES AS FACTOR XIA INHIBITORS | Bristol-Myers Squibb Company (US) | 2012-12-19 | — | — | EP | disclosed |
| WO-2011100401-A1 | MACROCYCLES AS FACTOR XIA INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2011-08-18 | — | — | WO | disclosed |