Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SREBF2 | Q12772 | 1/20 | 0.39 |
| ▸ | AAK1 | Q2M2I8 | 4/20 | 0.31 |
| ▸ | SYK | P43405 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL615587 | 1.00 | SREBF2 (0.39) | SREBF2AAK1SYK | |
| SCHEMBL2236027 | 0.95 | SREBF2 (0.36) | SREBF2 | |
| SCHEMBL613985 | 0.95 | SREBF2 (0.36) | SREBF2 | |
| SCHEMBL616659 | 0.84 | SREBF2 (0.38) | SREBF2AAK1 | |
| SCHEMBL2234474 | 0.84 | SREBF2 (0.38) | SREBF2AAK1 | |
| SCHEMBL615586 | 0.83 | AAK1 (0.34) | SREBF2AAK1SYK | |
| Hydrochloric Acid SCHEMBL30194190 | 0.83 | AAK1 (0.34) | SREBF2AAK1SYK | |
| SCHEMBL2236917 | 0.80 | SREBF2 (0.38) | SREBF2AAK1 | |
| SCHEMBL614167 | 0.80 | SREBF2 (0.36) | SREBF2 | |
| SCHEMBL613984 | 0.79 | P2RY12 (0.33) | SREBF2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2534154-A1 | MACROCYCLES AS FACTOR XIA INHIBITORS | Bristol-Myers Squibb Company (US) | 2012-12-19 | — | — | EP | disclosed |
| WO-2011100401-A1 | MACROCYCLES AS FACTOR XIA INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2011-08-18 | — | — | WO | disclosed |