Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.45 |
| ▸ | PRNP | P04156 | 2/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.42 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.40 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | TDP2 | O95551 | 1/20 | 0.38 |
| ▸ | NSD2 | O96028 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22345541 | 0.86 | CYP2C9 (0.40) | CYP2C9KDM4EPRNPRXFP1USP2 | |
| Iodide SCHEMBL22345407 | 0.83 | RXFP1 (0.51) | KDM4EPRNPRXFP1USP2MCL1 | |
| SCHEMBL1147520 | 0.75 | KDM4E (0.65) | CYP2C9KDM4EPRNPRXFP1USP2 | |
| Hydrochloric Acid SCHEMBL22345579 | 0.74 | HDAC6 (0.45) | PRNPRXFP1FFAR1POLBL3MBTL1 | |
| SCHEMBL28634474 | 0.72 | HDAC6 (0.46) | PRNPRXFP1FFAR1POLBL3MBTL1 | |
| SCHEMBL9379905 | 0.70 | CYP2C9 (0.68) | CYP2C9KDM4EPRNPRXFP1USP2 | |
| SCHEMBL10673820 | 0.69 | CYP2C9 (1.00) | CYP2C9KDM4EPRNPRXFP1USP2 | |
| Hydrochloric Acid SCHEMBL28623589 | 0.68 | USP5 (0.33) | PRNPRXFP1HSD17B10 | |
| SCHEMBL14273063 | 0.67 | CYP1A2 (0.73) | CYP2C9KDM4EPRNPRXFP1CYP1A2 | |
| SCHEMBL18499105 | 0.67 | CYP2C9 (0.63) | CYP2C9KDM4EPRNPRXFP1USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220132847-A1 | CINNOLINIUM COMPOUNDS FOR USE IN A METHOD OF CONTROLLING UNWANTED PLANT GROWTH | SYNGENTA CROP PROTECTION AG (CH) | 2022-05-05 | — | — | US | disclosed |
| EP-3924344-A1 | CINNOLINIUM COMPOUNDS FOR USE IN A METHOD OF CONTROLLING UNWANTED PLANT GROWTH | Syngenta Crop Protection AG (CH) | 2021-12-22 | — | — | EP | disclosed |
| WO-2020164970-A1 | CINNOLINIUM COMPOUNDS FOR USE IN A METHOD OF CONTROLLING UNWANTED PLANT GROWTH | SYNGENTA CROP PROTECTION AG (CH) | 2020-08-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220132847-A1 | CINNOLINIUM COMPOUNDS FOR USE IN A METHOD OF CONTROLLING UNWANTED PLANT GROWTH | NOTUM, DDT, CYP51A1 | CYP2C9 255/4885KDM4E 3584/4885PRNP 4883/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.