Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 16/20 | 0.74 |
| ▸ | JAK3 | P52333 | 15/20 | 0.74 |
| ▸ | LCK | P06239 | 10/20 | 0.74 |
| ▸ | EGFR | P00533 | 6/20 | 0.74 |
| ▸ | CAMK1D | Q8IU85 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22358871 | 1.00 | BTK (0.74) | BTKJAK3LCKEGFRCAMK1D | |
| SCHEMBL22346874 | 1.00 | BTK (0.74) | BTKJAK3LCKEGFRCAMK1D | |
| SCHEMBL28856962 | 0.88 | BTK (0.70) | BTKJAK3LCKEGFR | |
| SCHEMBL28856964 | 0.88 | BTK (0.70) | BTKJAK3LCKEGFR | |
| SCHEMBL22346837 | 0.88 | BTK (0.83) | BTKJAK3LCKEGFR | |
| SCHEMBL22346828 | 0.88 | BTK (0.83) | BTKJAK3LCKEGFR | |
| SCHEMBL16801848 | 0.87 | JAK3 (0.73) | BTKJAK3LCKEGFR | |
| SCHEMBL16764515 | 0.85 | BTK (1.00) | BTKJAK3LCKEGFR | |
| SCHEMBL16764351 | 0.85 | BTK (1.00) | BTKJAK3LCKEGFR | |
| SCHEMBL16764007 | 0.85 | JAK3 (1.00) | BTKJAK3LCKEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3924350-A1 | BIFUNCTIONAL COMPOUNDS FOR DEGRADING BTK VIA UBIQUITIN PROTEOSOME PATHWAY | Nurix Therapeutics, Inc. (US) | 2021-12-22 | — | — | EP | disclosed |
| WO-2020167518-A1 | BIFUNCTIONAL COMPOUNDS FOR DEGRADING BTK VIA UBIQUITIN PROTEOSOME PATHWAY | NURIX THERAPEUTICS, INC. (US) | 2020-08-20 | — | — | WO | disclosed |