Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 17/20 | 0.70 |
| ▸ | JAK3 | P52333 | 16/20 | 0.70 |
| ▸ | LCK | P06239 | 12/20 | 0.70 |
| ▸ | EGFR | P00533 | 7/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28856964 | 1.00 | BTK (0.70) | BTKJAK3LCKEGFR | |
| SCHEMBL28856902 | 0.90 | JAK3 (0.65) | BTKJAK3LCKEGFR | |
| SCHEMBL22346874 | 0.88 | BTK (0.74) | BTKJAK3LCKEGFR | |
| SCHEMBL22346053 | 0.88 | BTK (0.74) | BTKJAK3LCKEGFR | |
| SCHEMBL22358871 | 0.88 | BTK (0.74) | BTKJAK3LCKEGFR | |
| SCHEMBL28856968 | 0.87 | JAK3 (0.54) | BTKJAK3LCKEGFR | |
| SCHEMBL28856965 | 0.87 | JAK3 (0.54) | BTKJAK3LCKEGFR | |
| SCHEMBL22346828 | 0.84 | BTK (0.83) | BTKJAK3LCKEGFR | |
| SCHEMBL22346837 | 0.84 | BTK (0.83) | BTKJAK3LCKEGFR | |
| SCHEMBL16801848 | 0.84 | JAK3 (0.73) | BTKJAK3LCKEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115003304-A | Bifunctional compounds for the degradation of BTK via the ubiquitin proteasome pathway | 纽力克斯治疗公司 | 2022-09-02 | — | — | CN | disclosed |