Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.62 |
| ▸ | TTBK1 | Q5TCY1 | 6/20 | 0.53 |
| ▸ | TTBK2 | Q6IQ55 | 6/20 | 0.53 |
| ▸ | EGFR | P00533 | 4/20 | 0.52 |
| ▸ | JAK2 | O60674 | 1/20 | 0.52 |
| ▸ | JAK1 | P23458 | 1/20 | 0.52 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.50 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.49 |
| ▸ | PDE5A | O76074 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | HPGDS | O60760 | 1/20 | 0.46 |
| ▸ | GALR3 | O60755 | 1/20 | 0.44 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4354437 | 0.86 | JAK2 (0.68) | HDAC6TTBK1TTBK2EGFRJAK2 | |
| SCHEMBL24804993 | 0.85 | HDAC6 (0.66) | HDAC6TTBK1TTBK2EGFRJAK2 | |
| SCHEMBL17527397 | 0.80 | TTBK1 (0.65) | HDAC6TTBK1TTBK2EGFRPDE5A | |
| SCHEMBL24805950 | 0.77 | HDAC6 (0.60) | HDAC6TTBK1TTBK2EGFRJAK2 | |
| SCHEMBL20119853 | 0.77 | JAK2 (0.46) | HDAC6EGFRJAK2JAK1PDE5A | |
| SCHEMBL20119397 | 0.77 | PDE5A (0.48) | HDAC6TTBK1TTBK2JAK2PDE5A | |
| SCHEMBL29833956 | 0.77 | PDE5A (0.48) | HDAC6TTBK1TTBK2JAK2PDE5A | |
| SCHEMBL15950904 | 0.76 | LMNA (0.47) | EGFRJAK2JAK1DYRK1APTK2 | |
| SCHEMBL28762132 | 0.76 | TTBK1 (0.56) | HDAC6TTBK1TTBK2HPGDS | |
| SCHEMBL22347023 | 0.75 | TSHR (0.63) | HDAC6EGFRDYRK1ALMNARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3924050-A1 | PYRROLO[2,3-D]PYRIMIDINE COMPOUNDS FOR TREATING FAMILIAL DYSAUTONOMIA | PTC Therapeutics, Inc. (US) | 2021-12-22 | — | — | EP | claimed |
| WO-2020167624-A1 | PYRROLO[2,3-D]PYRIMIDINE COMPOUNDS FOR TREATING FAMILIAL DYSAUTONOMIA | PTC THERAPEUTICS, INC. (US) | 2020-08-20 | — | — | WO | claimed |