SCHEMBL22347199

SCHEMBL22347199

COC(=O)C12CCC(C(=O)NC[C@H](C)O)(CC1)CC2

nearest known ligand 0.37

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
CHRM1 P11229 1/20 0.37
HSD17B10 Q99714 2/20 0.33
HSD11B1 P28845 1/20 0.33
TSHR P16473 1/20 0.33
CYP2D6 P10635 1/20 0.31
CYP2C19 P33261 1/20 0.31
MEN1 O00255 2/20 0.31
KMT2A Q03164 2/20 0.31
KDM4E B2RXH2 1/20 0.31
ALDH1A1 P00352 1/20 0.31
HPGD P15428 1/20 0.31
MAPK1 P28482 1/20 0.31
NPSR1 Q6W5P4 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22348421 1.00 CHRM1 (0.37) CHRM1HSD17B10HSD11B1TSHRCYP2D6
SCHEMBL22347229 0.79 TSHR (0.42) CHRM1HSD17B10HSD11B1TSHRMEN1
SCHEMBL2445606 0.74 NPSR1 (0.46) CHRM1HSD11B1TSHRMEN1KMT2A
SCHEMBL22354350 0.72 NPSR1 (0.35) CHRM1HSD11B1NPSR1
SCHEMBL1679811 0.71 HSD11B1 (0.39) CHRM1HSD11B1MAPK1NPSR1
SCHEMBL23744215 0.70 NPSR1 (0.36) CHRM1HSD11B1NPSR1
SCHEMBL15114116 0.70 NPSR1 (0.36) CHRM1HSD11B1NPSR1
SCHEMBL10159969 0.69 CHRM1 (0.36) CHRM1HSD11B1TSHRCYP2D6CYP2C19
SCHEMBL2451039 0.68 NPSR1 (0.46) CHRM1HSD11B1MEN1KMT2AALDH1A1
SCHEMBL24979531 0.68 CYP3A4 (0.35) CYP2C19ALDH1A1HPGDNPSR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3924336-A1 SUBSTITUTED BICYCLIC COMPOUNDS AS FARNESOID X RECEPTOR MODULATORS Bristol-Myers Squibb Company (US) 2021-12-22 EP disclosed
WO-2020168143-A1 SUBSTITUTED BICYCLIC COMPOUNDS AS FARNESOID X RECEPTOR MODULATORS BRISTOL-MYERS SQUIBB COMPANY (US) 2020-08-20 WO disclosed