Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | RHOA | P61586 | 2/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | PIM2 | Q9P1W9 | 6/20 | 0.38 |
| ▸ | PIM1 | P11309 | 1/20 | 0.37 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.37 |
| ▸ | IP6K3 | Q96PC2 | 1/20 | 0.37 |
| ▸ | IP6K2 | Q9UHH9 | 1/20 | 0.37 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.37 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.37 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22350196 | 0.91 | NR1H4 (0.46) | MAPTKMT2AALDH1A1IP6K1IP6K3 | |
| SCHEMBL29900958 | 0.91 | NR1H4 (0.46) | MAPTKMT2AALDH1A1IP6K1IP6K3 | |
| SCHEMBL22350202 | 0.85 | NR1H4 (0.45) | KMT2AALDH1A1IP6K1IP6K3IP6K2 | |
| SCHEMBL22347581 | 0.85 | NR1H4 (0.51) | GLAMAPTMEN1KMT2ACYP2C9 | |
| SCHEMBL22348156 | 0.83 | GLA (0.43) | GLAMAPTMEN1KMT2ACYP2C9 | |
| SCHEMBL22347911 | 0.80 | PKM (0.49) | GLAMAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL22347795 | 0.79 | NR1H4 (0.53) | CYP2C9NR1H4 | |
| SCHEMBL22347967 | 0.77 | PIM2 (0.45) | MAPTMEN1KMT2AALDH1A1RHOA | |
| SCHEMBL22348757 | 0.76 | PKM (0.43) | GLAMAPTMEN1KMT2ARHOA | |
| SCHEMBL22350405 | 0.76 | NR1H4 (0.61) | MAPTKMT2AALDH1A1IP6K1IP6K3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3924329-A2 | SUBSTITUTED AMIDE COMPOUNDS USEFUL AS FARNESOID X RECEPTOR MODULATORS | Bristol-Myers Squibb Company (US) | 2021-12-22 | — | — | EP | disclosed |
| WO-2020168152-A2 | SUBSTITUTED AMIDE COMPOUNDS USEFUL AS FARNESOID X RECEPTOR MODULATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2020-08-20 | — | — | WO | disclosed |