Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 7/20 | 0.42 |
| ▸ | BRAF | P15056 | 10/20 | 0.42 |
| ▸ | RAF1 | P04049 | 6/20 | 0.39 |
| ▸ | CSF1R | P07333 | 3/20 | 0.39 |
| ▸ | DDR1 | Q08345 | 3/20 | 0.39 |
| ▸ | DDR2 | Q16832 | 3/20 | 0.39 |
| ▸ | F2 | P00734 | 2/20 | 0.38 |
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | F10 | P00742 | 1/20 | 0.38 |
| ▸ | SYK | P43405 | 1/20 | 0.37 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.37 |
| ▸ | ERN1 | O75460 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2233267 | 0.90 | IRAK4 (0.41) | IRAK4BRAFRAF1CSF1RDDR1 | |
| SCHEMBL2234672 | 0.90 | IRAK4 (0.46) | IRAK4BRAFRAF1CSF1RDDR1 | |
| SCHEMBL2233325 | 0.89 | L3MBTL1 (0.39) | IRAK4BRAFRAF1CSF1RDDR1 | |
| SCHEMBL2233853 | 0.88 | IRAK4 (0.43) | IRAK4BRAFRAF1CSF1RDDR1 | |
| SCHEMBL2233318 | 0.88 | FGFR3 (0.43) | IRAK4BRAFRAF1F2F10 | |
| SCHEMBL2233046 | 0.86 | IRAK4 (0.39) | IRAK4BRAFRAF1F2F10 | |
| SCHEMBL2236308 | 0.86 | BRAF (0.42) | IRAK4BRAFRAF1CSF1RDDR1 | |
| SCHEMBL14125300 | 0.86 | IRAK4 (0.44) | IRAK4BRAFRAF1CSF1RDDR1 | |
| SCHEMBL14125285 | 0.86 | BRAF (0.40) | IRAK4BRAFRAF1CSF1RDDR1 | |
| SCHEMBL2233801 | 0.85 | MAPK1 (0.45) | IRAK4BRAFRAF1CSF1RDDR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2528920-A2 | BICYCLIC HETEROARYL DERIVATIVES HAVING INHIBITORY ACTIVITY FOR PROTEIN KINASE | Hanmi Pharm. Co., Ltd. (KR) | 2012-12-05 | — | — | EP | claimed |
| WO-2011093672-A2 | BICYCLIC HETEROARYL DERIVATIVES HAVING INHIBITORY ACTIVITY FOR PROTEIN KINASE | HANMI PHARM. CO., LTD. (KR) | 2011-08-04 | — | — | WO | claimed |