Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 19/20 | 0.35 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22348307 | 0.78 | NR1H4 (0.41) | NR1H4NR1I2CYP2C9CYP2C19 | |
| SCHEMBL22347673 | 0.76 | NR1H4 (0.41) | NR1H4NR1I2CYP2C9CYP2C19 | |
| SCHEMBL22347587 | 0.76 | NR1H4 (0.34) | NR1H4NR1I2CYP2C9CYP2C19 | |
| SCHEMBL22348463 | 0.73 | MGLL (0.39) | NR1H4NR1I2CYP2C9CYP2C19 | |
| SCHEMBL29784248 | 0.73 | HTT (0.41) | NR1H4 | |
| SCHEMBL22348525 | 0.71 | NR1H4 (0.42) | NR1H4NR1I2CYP2C9CYP2C19 | |
| SCHEMBL22348653 | 0.71 | NR1H4 (0.35) | NR1H4NR1I2CYP2C9CYP2C19 | |
| SCHEMBL13230295 | 0.70 | PIK3CG (0.36) | — | |
| SCHEMBL6370598 | 0.70 | PIK3CG (0.33) | — | |
| Hydrochloric Acid SCHEMBL2392011 | 0.69 | PIK3CG (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3924333-A1 | SUBSTITUTED AMIDE COMPOUNDS USEFUL AS FARNESOID X RECEPTOR MODULATORS | Bristol-Myers Squibb Company (US) | 2021-12-22 | — | — | EP | disclosed |
| WO-2020168149-A1 | SUBSTITUTED AMIDE COMPOUNDS USEFUL AS FARNESOID X RECEPTOR MODULATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2020-08-20 | — | — | WO | disclosed |