Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 4/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.46 |
| ▸ | THPO | P40225 | 3/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.44 |
| ▸ | LMNA | P02545 | 5/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | BLM | P54132 | 3/20 | 0.44 |
| ▸ | GFER | P55789 | 3/20 | 0.44 |
| ▸ | PMP22 | Q01453 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | GMNN | O75496 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14870034 | 1.00 | MAPT (0.46) | MAPTHSD17B10MAPK1HIF1AALOX15 | |
| SCHEMBL14869800 | 1.00 | MAPT (0.46) | MAPTHSD17B10MAPK1HIF1AALOX15 | |
| SCHEMBL14872470 | 0.90 | MAPT (0.46) | MAPTHSD17B10MAPK1HIF1AALOX15 | |
| SCHEMBL14869968 | 0.87 | ALPG (0.46) | MAPTHSD17B10MAPK1HIF1AALOX15 | |
| SCHEMBL14869985 | 0.86 | MAPT (0.50) | MAPTHSD17B10MAPK1HIF1AALOX15 | |
| SCHEMBL15101650 | 0.83 | MAPT (0.42) | MAPTHSD17B10MAPK1HIF1AALOX15 | |
| SCHEMBL14870279 | 0.83 | MAPT (0.42) | MAPTHSD17B10MAPK1HIF1AALOX15 | |
| SCHEMBL14869974 | 0.83 | MAPT (0.43) | MAPTHSD17B10MAPK1HIF1AALOX15 | |
| SCHEMBL14870255 | 0.82 | SIGMAR1 (0.43) | HTR1ATAAR1HTR2AHTR3ASIGMAR1 | |
| SCHEMBL14870275 | 0.81 | TAAR1 (0.41) | HSD17B10MAPK1TSHRLMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2800561-B1 | BIGUANIDE COMPOSITIONS AND METHODS OF TREATING METABOLIC DISORDERS | ANJI PHARMA US LLC (US) | 2020-08-19 | — | — | EP | disclosed |