Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNJ5 | P48544 | 5/20 | 0.45 |
| ▸ | KCNJ3 | P48549 | 5/20 | 0.45 |
| ▸ | KCNJ6 | P48051 | 2/20 | 0.45 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.43 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.43 |
| ▸ | P2RX4 | Q99571 | 11/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.41 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19576816 | 0.86 | P2RX4 (0.54) | P2RX4 | |
| SCHEMBL20929133 | 0.83 | KCNJ5 (0.45) | KCNJ5KCNJ3KCNJ6ROCK2ROCK1 | |
| SCHEMBL24766587 | 0.81 | KCNJ6 (0.47) | KCNJ5KCNJ3KCNJ6ROCK2ROCK1 | |
| SCHEMBL22341461 | 0.80 | KCNJ6 (0.46) | KCNJ5KCNJ3KCNJ6ROCK2ROCK1 | |
| SCHEMBL22894463 | 0.71 | CLK2 (0.46) | KCNJ5KCNJ3KCNJ6ROCK2ROCK1 | |
| SCHEMBL22894360 | 0.71 | ROCK2 (0.48) | KCNJ5KCNJ3KCNJ6ROCK2ROCK1 | |
| SCHEMBL19576819 | 0.70 | P2RX4 (0.58) | KCNJ5KCNJ3KCNJ6P2RX4ALDH1A1 | |
| SCHEMBL29716818 | 0.70 | P2RX4 (0.58) | KCNJ5KCNJ3KCNJ6P2RX4ALDH1A1 | |
| SCHEMBL22353143 | 0.70 | KCNJ5 (0.44) | KCNJ5KCNJ3KCNJ6ROCK2ROCK1 | |
| SCHEMBL19576971 | 0.70 | KCNJ5 (0.48) | KCNJ5KCNJ3KCNJ6ROCK2ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3458443-B1 | AROMATIC SULFONAMIDE DERIVATIVES | Bayer Pharma AG (DE) | 2020-08-19 | — | — | EP | disclosed |