Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 3/20 | 0.36 |
| ▸ | JAK3 | P52333 | 2/20 | 0.36 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.35 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.35 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.33 |
| ▸ | GRM8 | O00222 | 1/20 | 0.33 |
| ▸ | TACR1 | P25103 | 1/20 | 0.33 |
| ▸ | GRM7 | Q14831 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20088855 | 0.84 | JAK2 (0.35) | JAK2JAK3TLR9TLR8TLR7 | |
| SCHEMBL22357554 | 0.78 | KDM4E (0.36) | LMNAKDM4EPOLBHPGDNPSR1 | |
| SCHEMBL20085798 | 0.72 | KDM4E (0.34) | TLR9TLR8TLR7LMNAKDM4E | |
| SCHEMBL20085811 | 0.72 | KDM4E (0.36) | TLR9TLR8TLR7LMNAKDM4E | |
| SCHEMBL20085799 | 0.72 | KDM4E (0.33) | TLR9TLR8TLR7LMNAKDM4E | |
| SCHEMBL19761021 | 0.72 | TLR9 (0.41) | TLR9TLR8TLR7MAPTLMNA | |
| SCHEMBL22357555 | 0.70 | PDE4B (0.39) | MAPTKDM4EHPGDPDE4BPDE3A | |
| SCHEMBL20088995 | 0.67 | KDM4E (0.35) | JAK2LMNATP53KDM4EPOLB | |
| SCHEMBL20085816 | 0.67 | LMNA (0.35) | MAPTLMNACYP1A2CYP2C9KDM4E | |
| SCHEMBL29556962 | 0.66 | DHODH (0.40) | LMNAKDM4EGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3532476-B1 | FUSED AZAHETEROCYCLIC COMPOUNDS AND THEIR USE AS AMPA RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2020-08-19 | — | — | EP | disclosed |