Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 17/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20116503 | 0.91 | GRM5 (0.47) | GRM5SMN1; SMN2KCNH2 | |
| SCHEMBL30506351 | 0.91 | GRM5 (0.47) | GRM5SMN1; SMN2KCNH2 | |
| SCHEMBL22357987 | 0.90 | GRM5 (0.42) | GRM5MAPTLMNAHTTSMN1; SMN2 | |
| SCHEMBL30506234 | 0.90 | GRM5 (0.42) | GRM5MAPTLMNAHTTSMN1; SMN2 | |
| SCHEMBL22357986 | 0.90 | GRM5 (0.42) | GRM5MAPTLMNAHTTSMN1; SMN2 | |
| SCHEMBL20116654 | 0.90 | GRM5 (0.42) | GRM5MAPTLMNAHTTSMN1; SMN2 | |
| SCHEMBL22357853 | 0.82 | GRM5 (0.42) | GRM5KCNH2 | |
| SCHEMBL22358113 | 0.82 | GRM5 (0.42) | GRM5KCNH2 | |
| SCHEMBL22357845 | 0.82 | GRM5 (0.42) | GRM5KCNH2 | |
| SCHEMBL22358157 | 0.80 | GRM5 (0.51) | GRM5LMNASMN1; SMN2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200262828-A1 | COMPOUNDS AND USES THEREOF | JANSSEN PHARMACEUTICA NV (BE) | 2020-08-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200262828-A1 | COMPOUNDS AND USES THEREOF | NLN, ACHE, CLN6 | GRM5 68/4885MAPT 22/4885LMNA 1966/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.