Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.43 |
| ▸ | RAB9A | P51151 | 4/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | NOS3 | P29474 | 2/20 | 0.40 |
| ▸ | NOS1 | P29475 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 4/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.39 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.39 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | STS | P08842 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20367492 | 0.76 | MAPT (0.46) | MAPTRAB9ANPC1MAPK1KDM4E | |
| SCHEMBL21205039 | 0.74 | MAPT (0.55) | MAPTRAB9ANPC1MAPK1KDM4E | |
| SCHEMBL8191180 | 0.71 | MAPT (0.55) | MAPTRAB9ANPC1MAPK1KDM4E | |
| SCHEMBL17292706 | 0.70 | ESR1 (0.45) | MAPTRAB9ANPC1MAPK1KDM4E | |
| SCHEMBL50646 | 0.69 | MAPT (0.68) | MAPTRAB9ANPC1MAPK1KDM4E | |
| SCHEMBL21003589 | 0.69 | KMT2A (0.36) | MAPTKDM4EKMT2ALMNAL3MBTL1 | |
| SCHEMBL21792294 | 0.69 | TYR (0.38) | MAPTRAB9ANPC1MAPK1KDM4E | |
| SCHEMBL20852278 | 0.69 | TAAR1 (0.39) | MAPK1L3MBTL1SMN1; SMN2ALDH1A1 | |
| SCHEMBL28717032 | 0.69 | MAPT (0.55) | MAPTRAB9ANPC1MAPK1KDM4E | |
| SCHEMBL16746562 | 0.69 | MAPT (0.59) | MAPTRAB9ANPC1MAPK1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3696181-A1 | PURINONES AS UBIQUITIN-SPECIFIC PROTEASE 1 INHIBITORS | Forma Therapeutics, Inc. (US) | 2020-08-19 | — | — | EP | disclosed |