Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.71 |
| ▸ | HMGCR | P04035 | 1/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.44 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | SLC13A5 | Q86YT5 | 5/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ACLY | P53396 | 3/20 | 0.37 |
| ▸ | CPT2 | P23786 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL28071316 | 0.98 | ALDH1A1 (0.68) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL28207935 | 0.98 | ALDH1A1 (0.68) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL28207936 | 0.98 | ALDH1A1 (0.68) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL28220035 | 0.92 | ALDH1A1 (0.60) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL27797802 | 0.92 | ALDH1A1 (0.60) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL27877323 | 0.90 | ALDH1A1 (0.79) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL28910158 | 0.88 | ALDH1A1 (0.56) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL27723689 | 0.88 | ALDH1A1 (0.75) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL27925643 | 0.87 | ALDH1A1 (0.83) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL23062790 | 0.87 | ALDH1A1 (0.94) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 39 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112730657-A | Analysis and detection method for rifapentine content | 卓和药业集团有限公司 | 2021-04-30 | — | — | CN | claimed |
| CN-103439444-A | High efficiency liquid chromatography method for detecting carnitine content in fish plasma | UNIV GUANGXI | 2013-12-11 | — | — | CN | claimed |
| CN-102707059-A | Colloidal gold test paper strip for residue detection of tylosin and tilmicosin, method for using colloidal gold test paper strip and application of colloidal gold test paper strip | UNIV HUAZHONG AGRICULTURAL | 2012-10-03 | — | — | CN | claimed |
| CN-118311169-A | Method for detecting N-nitrosonorminocycline-1 in medicine | 浙江海正药业股份有限公司 | 2024-07-09 | — | — | CN | disclosed |
| CN-118044537-A | Method for controlling mycotoxins in fruits | 中国科学院植物研究所 | 2024-05-17 | — | — | CN | disclosed |
| CN-116678977-A | Analysis method for simultaneously detecting florfenicol and metabolite thereof and three fluoroquinolone drug residues in eggs and poultry meat | 扬州大学 | 2023-09-01 | — | — | CN | disclosed |
| CN-113009016-B | Solid phase extraction bag and preparation method and application thereof | 南通市疾病预防控制中心 | 2023-05-12 | — | — | CN | disclosed |
| CN-114689767-A | Method for detecting aripiprazole raw material and related substances of aripiprazole preparation | 丽珠医药集团股份有限公司 | 2022-07-01 | — | — | CN | disclosed |
| CN-110283161-B | Crystal of pyridine substituted 2-aminopyridine protein kinase inhibitor | 正大天晴药业集团股份有限公司 | 2021-09-03 | — | — | CN | disclosed |
| CN-113009016-A | Solid-phase extraction bag and preparation method and application thereof | 南通市疾病预防控制中心 | 2021-06-22 | — | — | CN | disclosed |
| CN-112730657-A | Analysis and detection method for rifapentine content | 卓和药业集团有限公司 | 2021-04-30 | — | — | CN | disclosed |
| CN-101195614-B | Production of balofloxacin and purification process thereof | HENAN KANGTAI PHARMACY GROUP COMPANY | 2011-10-26 | — | — | CN | disclosed |
| WO-2011097525-A1 | SOLID STATE FORMS OF MACROCYCLIC KINASE INHIBITORS | TRAGARA PHARMACEUTICALS, INC. (US) | 2011-08-11 | — | — | WO | disclosed |
| CN-101879270-A | Chinese medicinal injectable powder and quality control method thereof | TIANJIN TASLY ZHIJIAO PHARM CO | 2010-11-10 | — | — | CN | disclosed |
| CN-101195614-A | Production of balofloxacin and purification process thereof | HENAN KANGTAI PHARMACY GROUP C (CN) | 2008-06-11 | — | — | CN | disclosed |
| CN-100377708-C | Method for preparing tablet of hydroxy camptothecin and oral application | HUANGSHI LISHIZHEN PHARMACY GR (CN) | 2008-04-02 | — | — | CN | disclosed |
| CN-1785431-A | Adjuvant of slow release agent used for eye and medicine containing said adjurant and its preparation method | CHENGDU SAMING MEDICINE INST (CN) | 2006-06-14 | — | — | CN | disclosed |
| CN-1695620-A | Method for preparing tablet of hydroxy camptothecin and oral application | HUANGSHI LISHIZHEN PHARMACY GR (CN) | 2005-11-16 | — | — | CN | disclosed |
| CN-1579402-A | Medicinal composition for treating bacterial conjunctivitis and keratitis and preparation and preparation method | SANMING MEDICINE INST CHENGDU (CN) | 2005-02-16 | — | — | CN | disclosed |
| US-4849136-A | Process for producing 7-amino-6-demethyl-6-deoxytetracycline | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1989-07-18 | — | — | US | disclosed |