Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 4/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | TAOK3 | Q9H2K8 | 1/20 | 0.47 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.45 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.43 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.43 |
| ▸ | PRMT5 | O14744 | 4/20 | 0.42 |
| ▸ | WDR77 | Q9BQA1 | 4/20 | 0.42 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.40 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.40 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | TERT | O14746 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30428022 | 1.00 | NAMPT (0.52) | NAMPTMAPK1TAOK3ABHD6DDB1 | |
| SCHEMBL9544207 | 0.85 | NAMPT (0.52) | NAMPTMAPK1TAOK3ABHD6DDB1 | |
| SCHEMBL9544216 | 0.85 | NAMPT (0.52) | NAMPTMAPK1TAOK3ABHD6DDB1 | |
| SCHEMBL29457612 | 0.81 | NAMPT (0.54) | NAMPTMAPK1TAOK3ABHD6DDB1 | |
| SCHEMBL11929935 | 0.81 | ABHD6 (0.65) | NAMPTMAPK1TAOK3ABHD6DDB1 | |
| SCHEMBL23257707 | 0.81 | NAMPT (0.54) | NAMPTMAPK1TAOK3ABHD6DDB1 | |
| SCHEMBL22319818 | 0.80 | ACE (0.38) | NAMPTABHD6 | |
| SCHEMBL22334380 | 0.80 | MAPK1 (0.52) | NAMPTMAPK1TAOK3ABHD6DDB1 | |
| SCHEMBL29813705 | 0.80 | NAMPT (0.53) | NAMPTMAPK1TAOK3ABHD6DDB1 | |
| SCHEMBL2902496 | 0.80 | NAMPT (0.53) | NAMPTMAPK1TAOK3ABHD6DDB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3700911-B1 | NOVEL MACROCYCLIC DERIVATIVES, PROCESS FOR PREPARING SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | SERVIER LAB (FR) | 2023-09-06 | — | — | EP | disclosed |
| EP-3700911-A1 | NOVEL MACROCYCLIC DERIVATIVES, PROCESS FOR PREPARING SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | Les Laboratoires Servier SAS (FR) | 2020-09-02 | — | — | EP | disclosed |