Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GBA1 | P04062 | 10/20 | 0.50 |
| ▸ | FUCA1 | P04066 | 4/20 | 0.44 |
| ▸ | GLA | P06280 | 2/20 | 0.44 |
| ▸ | GLB1 | P16278 | 1/20 | 0.44 |
| ▸ | MAN1B1 | Q9UKM7 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | PYGL | P06737 | 1/20 | 0.30 |
| ▸ | GBA2 | Q9HCG7 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7404065 | 0.77 | — | — | |
| SCHEMBL22768152 | 0.77 | — | — | |
| SCHEMBL17037474 | 0.77 | — | — | |
| SCHEMBL7405332 | 0.75 | — | — | |
| SCHEMBL23775007 | 0.70 | GBA1 (0.53) | GBA1FUCA1GLAGLB1MAN1B1 | |
| SCHEMBL6856714 | 0.68 | GBA1 (0.72) | GBA1FUCA1GLAGLB1MAN1B1 | |
| SCHEMBL20016401 | 0.68 | GBA1 (0.72) | GBA1FUCA1GLAGLB1MAN1B1 | |
| SCHEMBL6431779 | 0.68 | GBA1 (0.72) | GBA1FUCA1GLAGLB1MAN1B1 | |
| SCHEMBL16845146 | 0.68 | GBA1 (0.48) | GBA1FUCA1GLAGLB1MAN1B1 | |
| SCHEMBL21216447 | 0.67 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3390374-B1 | HYDROXYALKYLAMINE- AND HYDROXYCYCLOALKYLAMINE-SUBSTITUTED DIAMINE-ARYLSULFONAMIDE COMPOUNDS WITH SELECTIVE ACTIVITY IN VOLTAGE-GATED SODIUM CHANNELS | MERCK SHARP & DOHME (US) | 2020-08-26 | — | — | EP | disclosed |