Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 16/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 12/20 | 0.45 |
| ▸ | SCN1A | P35498 | 1/20 | 0.41 |
| ▸ | SCN5A | Q14524 | 5/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19008251 | 0.89 | SCN9A (0.43) | SCN9ACYP3A4SCN1ASCN5A | |
| SCHEMBL19008250 | 0.85 | SCN9A (0.44) | SCN9ACYP3A4SCN1ASCN5A | |
| SCHEMBL26761547 | 0.84 | SCN9A (0.45) | SCN9ACYP3A4SCN1ASCN5A | |
| SCHEMBL26761923 | 0.83 | SCN9A (0.42) | SCN9ACYP3A4SCN1ASCN5A | |
| SCHEMBL18983110 | 0.83 | SCN9A (0.67) | SCN9ACYP3A4SCN1ASCN5A | |
| SCHEMBL20182630 | 0.81 | SCN9A (0.48) | SCN9ACYP3A4SCN1ASCN5A | |
| SCHEMBL20182507 | 0.80 | SCN9A (0.47) | SCN9ACYP3A4SCN1ASCN5A | |
| SCHEMBL19000747 | 0.80 | SCN9A (0.49) | SCN9ACYP3A4SCN1ASCN5A | |
| SCHEMBL26761731 | 0.79 | SCN9A (0.44) | SCN9ACYP3A4SCN1ASCN5A | |
| SCHEMBL19008249 | 0.79 | SCN9A (0.38) | SCN9ACYP3A4SCN1ASCN5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3390374-B1 | HYDROXYALKYLAMINE- AND HYDROXYCYCLOALKYLAMINE-SUBSTITUTED DIAMINE-ARYLSULFONAMIDE COMPOUNDS WITH SELECTIVE ACTIVITY IN VOLTAGE-GATED SODIUM CHANNELS | MERCK SHARP & DOHME (US) | 2020-08-26 | — | — | EP | disclosed |