Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 14/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 12/20 | 0.48 |
| ▸ | SCN1A | P35498 | 1/20 | 0.43 |
| ▸ | SCN5A | Q14524 | 7/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26761547 | 0.86 | SCN9A (0.45) | SCN9ACYP3A4SCN1ASCN5A | |
| SCHEMBL20167423 | 0.84 | SCN9A (0.69) | SCN9ACYP3A4SCN1ASCN5A | |
| SCHEMBL30626723 | 0.84 | SCN9A (0.69) | SCN9ACYP3A4SCN1ASCN5A | |
| SCHEMBL20182506 | 0.84 | SCN9A (0.44) | SCN9ACYP3A4SCN1ASCN5A | |
| SCHEMBL19000747 | 0.84 | SCN9A (0.49) | SCN9ACYP3A4SCN1ASCN5A | |
| SCHEMBL20182507 | 0.82 | SCN9A (0.47) | SCN9ACYP3A4SCN1ASCN5A | |
| SCHEMBL26761731 | 0.82 | SCN9A (0.44) | SCN9ACYP3A4SCN1ASCN5A | |
| SCHEMBL23913156 | 0.81 | SCN9A (0.67) | SCN9ACYP3A4SCN1ASCN5A | |
| SCHEMBL22368378 | 0.81 | SCN9A (0.45) | SCN9ACYP3A4SCN1ASCN5A | |
| SCHEMBL25974284 | 0.80 | SCN9A (0.48) | SCN9ACYP3A4SCN1ASCN5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3541373-B1 | DIAMINO-ALKYLAMINO-LINKED ARYLSULFONAMIDE COMPOUNDS WITH SELECTIVE ACTIVITY IN VOLTAGE-GATED SODIUM CHANNELS | MERCK SHARP & DOHME LLC (US) | 2023-11-01 | — | — | EP | disclosed |
| WO-2018093694-A1 | DIAMINO-ALKYLAMINO-LINKED ARYLSULFONAMIDE COMPOUNDS WITH SELECTIVE ACTIVITY IN VOLTAGE-GATED SODIUM CHANNELS | MERCK SHARP & DOHME CORP. (US) | 2018-05-24 | — | — | WO | disclosed |