Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 16/20 | 0.60 |
| ▸ | TLR7 | Q9NYK1 | 5/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.39 |
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.39 |
| ▸ | HRH2 | P25021 | 2/20 | 0.39 |
| ▸ | HRH1 | P35367 | 2/20 | 0.39 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19991825 | 0.91 | TLR8 (0.59) | TLR8TLR7KCNH2HRH4HRH3 | |
| SCHEMBL19940713 | 0.91 | TLR8 (0.59) | TLR8TLR7KCNH2HRH4HRH3 | |
| SCHEMBL23025601 | 0.88 | TLR8 (0.61) | TLR8TLR7KCNH2HRH4HRH3 | |
| SCHEMBL18125192 | 0.81 | TLR8 (0.61) | TLR8TLR7NLRP3 | |
| SCHEMBL18923203 | 0.81 | TLR8 (0.61) | TLR8TLR7NLRP3 | |
| SCHEMBL19940969 | 0.80 | TLR8 (0.60) | TLR8TLR7NLRP3 | |
| SCHEMBL18109286 | 0.80 | TLR8 (0.74) | TLR8TLR7KCNH2NLRP3 | |
| SCHEMBL19940722 | 0.80 | TLR8 (0.60) | TLR8TLR7NLRP3 | |
| SCHEMBL18109289 | 0.80 | TLR8 (0.74) | TLR8TLR7KCNH2NLRP3 | |
| SCHEMBL18109542 | 0.80 | TLR8 (0.75) | TLR8TLR7KCNH2NLRP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3507288-B1 | 4,6-DIAMINO-PYRIDO[3,2-D]PYRIMIDINE DERIVATIES AS TOLL LIKE RECEPTOR MODULATORS | GILEAD SCIENCES INC (US) | 2020-08-26 | — | — | EP | disclosed |