Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | BRD4 | O60885 | 2/20 | 0.46 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.40 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.40 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.38 |
| ▸ | KIF11 | P52732 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6971113 | 0.81 | BRD4 (0.49) | BRD4CREBBPKDM4ELMNACHRM2 | |
| SCHEMBL2408663 | 0.78 | MAPT (0.53) | MAPTBRD4CREBBPNPC1MAPK13 | |
| SCHEMBL8523665 | 0.76 | MAPT (0.55) | MAPTBRD4CREBBPNPC1MAPK13 | |
| SCHEMBL427457 | 0.75 | MAPT (0.53) | MAPTNPC1MAPK13MAPK12MAPK11 | |
| SCHEMBL6407953 | 0.75 | MAPT (0.53) | MAPTBRD4CREBBPNPC1MAPK13 | |
| SCHEMBL97660 | 0.75 | NPC1 (0.47) | MAPTNPC1MAPK13MAPK12MAPK11 | |
| SCHEMBL22368946 | 0.72 | CREBBP (0.57) | MAPTBRD4CREBBPNPC1MAPK13 | |
| SCHEMBL11739357 | 0.71 | CYP2A6 (0.44) | MAPTBRD4KDM4EHTR1AMAPK1 | |
| SCHEMBL885653 | 0.71 | MAPT (0.49) | MAPTBRD4CREBBPNPC1MAPK13 | |
| SCHEMBL3052448 | 0.71 | MAPT (0.53) | MAPTBRD4CREBBPNPC1MAPK13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3204360-B1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | GENENTECH INC (US) | 2020-08-26 | — | — | EP | disclosed |