SCHEMBL6971113

SCHEMBL6971113

C#Cc1cccc2c1CC(=O)N2

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
BRD4 O60885 1/20 0.49
CREBBP Q92793 1/20 0.49
DRD2 P14416 4/20 0.46
DRD4 P21917 3/20 0.46
DRD3 P35462 3/20 0.46
KDM4E B2RXH2 1/20 0.46
LMNA P02545 1/20 0.46
CHRM2 P08172 1/20 0.46
CYP3A4 P08684 1/20 0.46
HTR1A P08908 1/20 0.46
ADRA2A P08913 1/20 0.46
CYP2D6 P10635 1/20 0.46
CYP2C9 P11712 1/20 0.46
ADRA2B P18089 1/20 0.46
DRD1 P21728 1/20 0.46
DRD5 P21918 1/20 0.46
HTR2A P28223 1/20 0.46
MAPK1 P28482 1/20 0.46
CYP2C19 P33261 1/20 0.46
ADRA1A P35348 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1402228 0.84 DRD2 (0.47) DRD2DRD4DRD3KDM4ELMNA
SCHEMBL22368762 0.81 MAPT (0.49) BRD4CREBBPDRD2DRD4DRD3
SCHEMBL624585 0.76 CCNB2 (0.54) DRD2DRD4DRD3KDM4ELMNA
SCHEMBL29622057 0.76 CCNB2 (0.54) DRD2DRD4DRD3KDM4ELMNA
SCHEMBL2511443 0.72 TDP2 (0.53) DRD2DRD4DRD3KDM4ELMNA
SCHEMBL152281 0.72 CCNB2 (0.54) BRD4CREBBPDRD2DRD4DRD3
SCHEMBL12326143 0.72 AHR (0.48) DRD2DRD4DRD3KDM4ELMNA
SCHEMBL261277 0.72 AHR (0.48) DRD2DRD4DRD3KDM4ELMNA
SCHEMBL3340538 0.72 AHR (0.48) DRD2DRD4DRD3KDM4ELMNA
SCHEMBL836954 0.72 AHR (0.48) DRD2DRD4DRD3KDM4ELMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1147486-C 4-and 5-alkynyloxindoles and 4-and 5-alkenyloxindoles - 2004-04-28 CN disclosed
EP-1149092-B1 4- AND 5-ALKYNYLOXINDOLES AND 4- AND 5-ALKENYLOXINDOLES HOFFMANN LA ROCHE (CH) 2003-10-29 EP disclosed
US-6313310-B1 JUN N-TERMINAL KINASE (JNK) ENZYME INHIBITORS; ANTIINFLAMMATORY AGENTS; RHEUMATIC ARTHRITIS AND NEURO-DEGENERATIVE DISEASE TREATMENT HOFFMANN-LA ROCHE INC. 2001-11-06 US disclosed
EP-1149092-A2 4- AND 5-ALKYNYLOXINDOLES AND 4- AND 5-ALKENYLOXINDOLES F. HOFFMANN-LA ROCHE AG (CH) 2001-10-31 EP disclosed
WO-2000035906-A2 4- AND 5-ALKYNYLOXINDOLES AND 4- AND 5-ALKENYLOXINDOLES F. HOFFMANN-LA ROCHE AG (CH) 2000-06-22 WO disclosed