Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 2/20 | 0.59 |
| ▸ | TOP2B | Q02880 | 2/20 | 0.59 |
| ▸ | MAOB | P27338 | 6/20 | 0.36 |
| ▸ | AKT2 | P31751 | 2/20 | 0.35 |
| ▸ | BACE1 | P56817 | 2/20 | 0.35 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.33 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.33 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.33 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TAAR1 | Q96RJ0 | 5/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.33 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14029046 | 0.84 | TOP2A (0.78) | TOP2ATOP2BNPC1TP53RAB9A | |
| SCHEMBL15402084 | 0.78 | TOP2A (0.51) | TOP2ATOP2BNPC1TP53RAB9A | |
| SCHEMBL14153121 | 0.77 | TOP2A (0.68) | TOP2ATOP2BNPC1TP53RAB9A | |
| SCHEMBL549309 | 0.75 | TOP2A (1.00) | TOP2ATOP2BNPC1TP53RAB9A | |
| SCHEMBL1936814 | 0.74 | TOP2A (0.46) | TOP2ATOP2BNPC1TP53RAB9A | |
| Hydrochloric Acid SCHEMBL7724236 | 0.74 | TOP2A (1.00) | TOP2ATOP2BNPC1TP53RAB9A | |
| SCHEMBL9114197 | 0.74 | TOP2A (0.58) | TOP2ATOP2BNPC1TP53RAB9A | |
| SCHEMBL9113764 | 0.74 | TOP2A (0.58) | TOP2ATOP2BNPC1TP53RAB9A | |
| Hydrochloric Acid SCHEMBL11547564 | 0.72 | TOP2A (0.59) | TOP2ATOP2BNPC1TP53RAB9A | |
| SCHEMBL12346612 | 0.72 | TOP2A (0.45) | TOP2ATOP2BNPC1TP53RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140073627-A1 | BRADYKININ B1 ANTAGONISTS | EVOTEC AG (DE) | 2014-03-13 | — | — | US | disclosed |
| US-8623859-B2 | Bradykinin B1 antagonists | EVOTEC AG (DE) | 2014-01-07 | — | — | US | disclosed |
| US-20110201589-A1 | NEW BRADYKININ B1 ANTAGONISTS | EVOTEC AG (DE) | 2011-08-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140073627-A1 | BRADYKININ B1 ANTAGONISTS | BDKRB1, BDKRB2, BRS3 | TOP2A 4511/4885TOP2B 2946/4885MAOB 176/4885 |
| US-20110201589-A1 | NEW BRADYKININ B1 ANTAGONISTS | BDKRB1, BDKRB2, BRS3 | TOP2A 4558/4885TOP2B 3251/4885MAOB 218/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.