Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 2/20 | 0.71 |
| ▸ | PTGS1 | P23219 | 6/20 | 0.70 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.70 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.70 |
| ▸ | TTR | P02766 | 4/20 | 0.70 |
| ▸ | MEN1 | O00255 | 3/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.70 |
| ▸ | TP53 | P04637 | 3/20 | 0.70 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.70 |
| ▸ | MAPT | P10636 | 3/20 | 0.70 |
| ▸ | HPGD | P15428 | 3/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.70 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.70 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.70 |
| ▸ | LMNA | P02545 | 3/20 | 0.70 |
| ▸ | CA12 | O43570 | 2/20 | 0.70 |
| ▸ | CA1 | P00915 | 2/20 | 0.70 |
| ▸ | CA2 | P00918 | 2/20 | 0.70 |
| ▸ | CA3 | P07451 | 2/20 | 0.70 |
| ▸ | CA4 | P22748 | 2/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pinosylvin SCHEMBL454262 | 1.00 | LCK (0.71) | LCKPTGS1KDM4EPTGS2TTR | |
| Pinosylvin SCHEMBL675667 | 1.00 | LCK (0.71) | LCKPTGS1KDM4EPTGS2TTR | |
| Pinosylvin SCHEMBL9419839 | 1.00 | LCK (0.71) | LCKPTGS1KDM4EPTGS2TTR | |
| Pinosylvin SCHEMBL3940383 | 1.00 | LCK (0.71) | LCKPTGS1KDM4EPTGS2TTR | |
| Pinosylvin SCHEMBL20455852 | 1.00 | LCK (0.71) | LCKPTGS1KDM4EPTGS2TTR | |
| Pinosylvin SCHEMBL7075363 | 1.00 | LCK (0.71) | LCKPTGS1KDM4EPTGS2TTR | |
| Pinosylvin SCHEMBL1586341 | 0.93 | KDM4E (0.72) | LCKPTGS1KDM4EPTGS2TTR | |
| Resveratrol SCHEMBL721421 | 0.93 | KDM4E (0.83) | LCKPTGS1KDM4EPTGS2TTR | |
| Resveratrol SCHEMBL7529004 | 0.93 | KDM4E (0.83) | LCKPTGS1KDM4EPTGS2TTR | |
| Pinosylvin SCHEMBL27484375 | 0.93 | KDM4E (0.72) | LCKPTGS1KDM4EPTGS2TTR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2362226-B1 | Diagnostic method for neurodegenerative diseases based on measurement of SIRT1 levels or activity | HARVARD COLLEGE (US) | 2016-02-17 | — | — | EP | disclosed |
| EP-2362226-A1 | Diagnostic method for neurodegenerative diseases based on measurement of SIRT1 levels or activity | The President and Fellows of Harvard College (US) | 2011-08-31 | — | — | EP | disclosed |