Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.42 |
| ▸ | IDH1 | O75874 | 10/20 | 0.41 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.40 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.40 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.40 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | AADAT | Q8N5Z0 | 1/20 | 0.35 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23050248 | 0.94 | IDH1 (0.42) | NOTUMIDH1GABRG2GABRB3GABRA5 | |
| SCHEMBL2235772 | 0.84 | IDH1 (0.38) | NOTUMIDH1GABRG2GABRB3GABRA5 | |
| SCHEMBL2234256 | 0.81 | NOTUM (0.38) | NOTUMIDH1GABRG2GABRB3GABRA5 | |
| SCHEMBL23050238 | 0.80 | IDH1 (0.41) | IDH1GABRG2GABRB3GABRA5HCAR1 | |
| SCHEMBL23037041 | 0.79 | IDH1 (0.43) | IDH1GABRG2GABRB3GABRA5HCAR1 | |
| SCHEMBL30511161 | 0.79 | IDH1 (0.43) | IDH1GABRG2GABRB3GABRA5HCAR1 | |
| SCHEMBL23770378 | 0.77 | IDH1 (0.37) | NOTUMIDH1GABRG2GABRB3GABRA5 | |
| SCHEMBL2235365 | 0.77 | MAPT (0.37) | — | |
| SCHEMBL2235371 | 0.77 | MAPT (0.37) | — | |
| SCHEMBL23037064 | 0.74 | IDH1 (0.49) | NOTUMIDH1GABRG2GABRB3GABRA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210253595-A1 | 2-Aminopyrimidine Derivative and Preparation Method and Use Thereof | ETERN BIOPHARMA (SHANGHAI) CO., LTD. (CN) | 2021-08-19 | — | — | US | disclosed |
| EP-3786166-A1 | 2-AMINOPYRIMIDINE DERIVATIVE, PREPARATION METHOD AND USE THEREOF | Etern Biopharma (Shanghai) Co., Ltd. (CN) | 2021-03-03 | — | — | EP | disclosed |
| US-20110213143-A1 | COMPOUND HAVING TAFIA INHIBITORY ACTIVITY | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2011-09-01 | — | — | US | disclosed |
| EP-2361910-A1 | COMPOUND HAVING TAFIA INHIBITORY ACTIVITY | Taisho Pharmaceutical Co., Ltd. (JP) | 2011-08-31 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110213143-A1 | COMPOUND HAVING TAFIA INHIBITORY ACTIVITY | TAF1, TAF5, TAF11 | NOTUM 547/4885IDH1 2972/4885GABRG2 2731/4885 |
| US-20210253595-A1 | 2-Aminopyrimidine Derivative and Preparation Method and Use Thereof | IDH1, IDH2, IDH3B | NOTUM 2590/4885IDH1 1/4885GABRG2 1980/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.