Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.43 |
| ▸ | XDH | P47989 | 1/20 | 0.42 |
| ▸ | CTSS | P25774 | 2/20 | 0.41 |
| ▸ | CTSK | P43235 | 2/20 | 0.41 |
| ▸ | CTSB | P07858 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | CTSG | P08311 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | CMA1 | P23946 | 1/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15037131 | 1.00 | EPHX2 (0.44) | EPHX2MAPTTDP1POLBROCK2 | |
| SCHEMBL15091963 | 0.88 | EPHX2 (0.47) | EPHX2XDHCTSSCTSKCTSB | |
| SCHEMBL15091968 | 0.88 | EPHX2 (0.47) | EPHX2XDHCTSSCTSKCTSB | |
| SCHEMBL15037039 | 0.87 | MAPT (0.46) | MAPTTDP1POLBROCK2MEN1 | |
| SCHEMBL16295279 | 0.87 | ROCK2 (0.49) | EPHX2MAPTTDP1POLBROCK2 | |
| SCHEMBL16342898 | 0.87 | MAPT (0.46) | MAPTTDP1POLBROCK2MEN1 | |
| SCHEMBL16295278 | 0.87 | ROCK2 (0.49) | EPHX2MAPTTDP1POLBROCK2 | |
| SCHEMBL22384169 | 0.87 | MAPT (0.45) | MAPTTDP1POLBROCK2MEN1 | |
| SCHEMBL28294750 | 0.86 | MAPT (0.50) | MAPTTDP1POLBROCK2MEN1 | |
| SCHEMBL28294749 | 0.86 | MAPT (0.50) | MAPTTDP1POLBROCK2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3008056-B1 | NOVEL GLP-1 RECEPTOR MODULATORS | CELGENE INT II SARL (CH) | 2020-12-09 | — | — | EP | disclosed |
| EP-2791112-B1 | CARBOXYLIC ACID DERIVATIVES COMPRISING FOUR CYCLES ACTING AS GLP-1 RECEPTOR MODULATORS FOR THERAPY OF DISEASES SUCH AS DIABETES | CELGENE INT II SÀRL (CH) | 2020-09-23 | — | — | EP | disclosed |
| EP-3230276-B1 | GLP-1 RECEPTOR MODULATORS | CELGENE INT II SARL (CH) | 2020-09-02 | — | — | EP | disclosed |
| CN-104080767-A | Novel GLP-1 receptor modulators | RECEPTOS INC | 2014-10-01 | — | — | CN | disclosed |