SCHEMBL22388727

SCHEMBL22388727

CC(C)(OC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(=O)OC(c1ccccc1)(c1ccc(C2CCCCCCC2)cc1)c1ccccc1Cl)NC(=O)OCC1c2ccccc2-c2ccccc21)c1ccccc1

nearest known ligand 0.39

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
▸ PRCP P42785 1/20 0.39
▸ MDM4 O15151 2/20 0.36
▸ TP53 P04637 2/20 0.36
▸ FDFT1 P37268 1/20 0.33
▸ BACE1 P56817 1/20 0.33
▸ CCR1 P32246 2/20 0.32
▸ ACE P12821 1/20 0.32
▸ ACE2 Q9BYF1 1/20 0.32
▸ MDM2 Q00987 1/20 0.32
▸ KLK5 Q9Y337 1/20 0.31
▸ CASP3 P42574 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22388726 1.00 PRCP (0.39) PRCPMDM4TP53FDFT1BACE1
SCHEMBL24828861 1.00 PRCP (0.39) PRCPMDM4TP53FDFT1BACE1
SCHEMBL26448326 0.93 PRCP (0.40) PRCPMDM4TP53FDFT1BACE1
SCHEMBL24579230 0.88 PRCP (0.39) PRCPACEACE2
SCHEMBL24414066 0.87 MDM4 (0.38) MDM4TP53BACE1CCR1MDM2
SCHEMBL24828833 0.87 MDM4 (0.38) MDM4TP53BACE1CCR1MDM2
SCHEMBL24414034 0.87 MDM4 (0.38) MDM4TP53BACE1CCR1MDM2
SCHEMBL21895947 0.87 MDM4 (0.38) MDM4TP53BACE1CCR1MDM2
SCHEMBL24965995 0.87 MDM4 (0.38) MDM4TP53BACE1CCR1MDM2
SCHEMBL24965903 0.87 MDM4 (0.38) MDM4TP53BACE1CCR1MDM2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11787836-B2 Method for synthesizing peptide containing N-substituted amino acid CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2023-10-17 — — US disclosed
US-20230138226-A1 METHOD FOR SYNTHESIZING PEPTIDE CONTAINING N-SUBSTITUTED AMINO ACID CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2023-05-04 — — US disclosed
US-11542299-B2 Method for synthesizing peptide containing N-substituted amino acid CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2023-01-03 — — US disclosed
US-20200277327-A1 METHOD FOR SYNTHESIZING PEPTIDE CONTAINING N-SUBSTITUTED AMINO ACID CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2020-09-03 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200277327-A1 METHOD FOR SYNTHESIZING PEPTIDE CONTAINING N-SUBSTITUTED AMINO ACID NPPA, VIP, DNPEP PRCP 68/4885MDM4 4142/4885TP53 2781/4885
US-20230138226-A1 METHOD FOR SYNTHESIZING PEPTIDE CONTAINING N-SUBSTITUTED AMINO ACID NPPA, VIP, DNPEP PRCP 68/4885MDM4 4142/4885TP53 2781/4885
US-11542299-B2 Method for synthesizing peptide containing N-substituted amino acid NPPA, VIP, DNPEP PRCP 68/4885MDM4 4142/4885TP53 2781/4885
US-11787836-B2 Method for synthesizing peptide containing N-substituted amino acid NPPA, VIP, DNPEP PRCP 68/4885MDM4 4142/4885TP53 2781/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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