NPPA — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL6807360	0.73	7/20
SCHEMBL6808018	0.68	7/20
SCHEMBL6806381	0.67	7/20
SCHEMBL6808651	0.65	7/20
SCHEMBL8334926	0.58	7/20
SCHEMBL6531174	0.51	7/20
SCHEMBL6256523	0.74	6/20
SCHEMBL6255996	0.73	6/20
SCHEMBL8334821	0.64	6/20
SCHEMBL6256519	0.64	6/20
SCHEMBL6255992	0.61	6/20
SCHEMBL6530510	0.61	6/20
SCHEMBL6530515	0.61	6/20
SCHEMBL6531169	0.61	6/20
SCHEMBL6531175	0.61	6/20
SCHEMBL6812430	0.60	6/20
SCHEMBL6807770	0.60	6/20
SCHEMBL6807772	0.60	6/20
SCHEMBL6812326	0.59	6/20
SCHEMBL6803882	0.57	6/20

Clinical trials — most relevant to NPPA by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
A Study Of The Usage Of Statins In A Community Heart Failure Population	PHASE4	COMPLETED
A Study Comparing Blood Flow and Clinical and Safety Effects of the Addition of Natrecor (Nesiritide), Placebo or Intravenous Nitroglycerin to Standard Care for the Treatment of Worsening Congestive Heart Failure.	PHASE3	COMPLETED
PRECISION-BP: Precision Chronopharamacotherapy Targeting NP-RAAS-BP Rhythm Axis	PHASE2/PHASE3	RECRUITING
Race, Natriuretic Peptides and Physiological Perturbations	PHASE2	COMPLETED
The Effects of Atorvastatin on the Nitric Oxide-system in Healthy Young Man	PHASE2	COMPLETED
Effects of Different Forms of a Natural Heart Hormone on Blood Pressure and Fluid Balance in Healthy Volunteers	EARLY_PHASE1	COMPLETED
Relationship of Brain Natriuretic Peptide (BNP) Levels to Cardiac Diagnosis, Operation Performed, Post-operative Course and Outcome	nan	COMPLETED
B-type Natriuretic Peptide as a Surrogate Marker Guiding Post-operative Fluid Off-loading	nan	COMPLETED
The Influence of NPPA/NPPB Haplotype on Natriuretic Peptide Plasma Levels	nan	COMPLETED
Neurological Prognostication of Patients in Therapeutic Hypothermia After Cardiac Arrest	nan	COMPLETED
A Cut-off Value Study of N-terminal Brain Natriuretic Peptide （Chemiluminescence Method）	nan	COMPLETED
Diagnostic and Prognostic Role of Troponin and Brain Natriuretic Peptide in Pediatric Patients With Cardiomyopathy in Correlation to Echocardiography Findings	nan	UNKNOWN
Effects of Nesiritide in Pediatric Patients With Heart Failure	nan	WITHDRAWN
Qatar Cardiovascular Biorepository of AF Patients	nan	UNKNOWN
BNP Evaluation Before Surgery Study: an Observational Study of Natriuretic Peptide Levels Prior to Surgery.	nan	COMPLETED
Alere Triage fs B-type Natriuretic Peptide (BNP) Method Comparison Evaluation	nan	COMPLETED
Influence of DPP-4 on Inflammatory Parameters in Diabetics: Gender Aspects	nan	UNKNOWN
Soluble ST2 in Patients With Heart Failure	nan	NOT_YET_RECRUITING
Cognitive Impairment in Patients With Heart Failure	nan	COMPLETED
Ankle Brachial Index Versus Conventional Cardiac Risk Indices	nan	UNKNOWN
Prevalence of Asymptomatic Ventricular Dysfunction	nan	COMPLETED
Lithuanian Echocardiography Study of Dyspnea in Acute Settings	nan	COMPLETED
The Natriuretic Peptide System in African-Americans.	nan	COMPLETED
ARgentinean Risk Assessment Registry in ACS; the ARRA-RACS Study	nan	COMPLETED
Analysis of Cardiac Biomarker Racial Discrepancies	nan	ENROLLING_BY_INVITATION
Biomarkers in Patients With Suspected HFpEF	nan	RECRUITING
Improving Diagnostic Accuracy for Acute Heart Failure	nan	ACTIVE_NOT_RECRUITING
ULtrafiltration-Rate Induced CArdiac Strain (ULRICA) - Study	nan	RECRUITING
Impact of Clinical, Demographic and Laboratory Variables on Brain Natriuretic Peptide Levels	nan	WITHDRAWN
The Diurnal Rhythm in Natriuretic Peptide Levels	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a NPPA binder may also engage these)

Protein	Name	Similarity
P24259	—	1.000	P24259 →
P27104	—	1.000	P27104 →
P07501	—	1.000	P07501 →
Q9GLD0	—	1.000	Q9GLD0 →
P07499	—	1.000	P07499 →
P05125	—	0.998	P05125 →
O46540	—	0.998	O46540 →
P07500	—	0.998	P07500 →
P27596	—	0.997	P27596 →
P01161	—	0.996	P01161 →
Q8AYR6	—	0.996	Q8AYR6 →
P18908	—	0.995	P18908 →
P55208	—	0.994	P55208 →
Q800I8	—	0.993	Q800I8 →
P26917	—	0.993	P26917 →
P18909	—	0.993	P18909 →
P41319	—	0.992	P41319 →
P60041	—	0.992	P60041 →
Q8AXR2	—	0.992	Q8AXR2 →
Q805D8	—	0.992	Q805D8 →
P18145	—	0.992	P18145 →
P83964	—	0.991	P83964 →
P49670	—	0.991	P49670 →
Q805D7	—	0.991	Q805D7 →
Q8AXR3	—	0.991	Q8AXR3 →
P01169	—	0.990	P01169 →
Q805D6	—	0.990	Q805D6 →
Q805E8	—	0.990	Q805E8 →
P23259	—	0.990	P23259 →
P01168	—	0.990	P01168 →