Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 20/20 | 0.66 |
| ▸ | ERBB3 | P21860 | 4/20 | 0.65 |
| ▸ | DUS2 | Q9NX74 | 1/20 | 0.65 |
| ▸ | ERBB2 | P04626 | 6/20 | 0.60 |
| ▸ | SRC | P12931 | 3/20 | 0.60 |
| ▸ | ERBB4 | Q15303 | 3/20 | 0.60 |
| ▸ | KIT | P10721 | 2/20 | 0.60 |
| ▸ | KDR | P35968 | 2/20 | 0.60 |
| ▸ | CIT | O14578 | 2/20 | 0.60 |
| ▸ | GAK | O14976 | 2/20 | 0.60 |
| ▸ | EPHB6 | O15197 | 2/20 | 0.60 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.60 |
| ▸ | STK10 | O94804 | 2/20 | 0.60 |
| ▸ | ABL1 | P00519 | 2/20 | 0.60 |
| ▸ | LCK | P06239 | 2/20 | 0.60 |
| ▸ | LYN | P07948 | 2/20 | 0.60 |
| ▸ | RET | P07949 | 2/20 | 0.60 |
| ▸ | MET | P08581 | 2/20 | 0.60 |
| ▸ | HCK | P08631 | 2/20 | 0.60 |
| ▸ | AXL | P30530 | 2/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27580641 | 0.86 | EGFR (0.65) | EGFRERBB3DUS2ERBB2SRC | |
| SCHEMBL22394465 | 0.85 | EGFR (0.61) | EGFRERBB3ERBB2SRCERBB4 | |
| Hydrochloric Acid SCHEMBL28384466 | 0.84 | EGFR (0.60) | EGFRERBB3ERBB2SRCERBB4 | |
| SCHEMBL4787463 | 0.83 | EGFR (0.70) | EGFRERBB3DUS2ERBB2SRC | |
| SCHEMBL2266659 | 0.80 | EGFR (1.00) | EGFRERBB3ERBB2SRCERBB4 | |
| SCHEMBL21801932 | 0.80 | EGFR (1.00) | EGFRERBB3DUS2ERBB2SRC | |
| SCHEMBL29478966 | 0.80 | EGFR (1.00) | EGFRERBB3DUS2ERBB2SRC | |
| SCHEMBL29617536 | 0.80 | EGFR (1.00) | EGFRERBB3DUS2ERBB2SRC | |
| SCHEMBL28428839 | 0.79 | KDR (0.52) | EGFRERBB3ERBB2SRCERBB4 | |
| SCHEMBL19634180 | 0.77 | EGFR (0.73) | EGFRERBB3DUS2ERBB2SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112955137-A | Combination therapy | 米拉蒂治疗股份有限公司 | 2021-06-11 | — | — | CN | claimed |
| CN-117327059-A | Compounds that inhibit and induce protein degradation | 北京泰德制药股份有限公司 | 2024-01-02 | — | — | CN | disclosed |
| CN-117222435-A | HER 2-targeted Fc antigen binding fragment-drug conjugates | 默克专利有限公司 | 2023-12-12 | — | — | CN | disclosed |
| CN-113912589-B | Compounds that inhibit and induce protein degradation | 北京泰德制药股份有限公司 | 2023-10-20 | — | — | CN | disclosed |
| WO-2023198180-A1 | EGFR DEGRADATION AGENT | 北京泰德制药股份有限公司 | 2023-10-19 | — | — | WO | disclosed |
| EP-3705478-B1 | TRIAZINE COMPOUND AND PHARMACEUTICALLY ACCEPTABLE SALT THEREOF | SHENZHEN FORWARD PHARMACEUTICALS CO LTD (CN) | 2023-10-04 | — | — | EP | disclosed |
| CN-114829364-B | Compounds that inhibit and induce degradation of EGFR kinase | 北京泰德制药股份有限公司 | 2023-08-22 | — | — | CN | disclosed |
| CN-116507337-A | ATR inhibitors and uses thereof | 上海德琪医药科技有限公司 | 2023-07-28 | — | — | CN | disclosed |
| CN-116462685-A | Heterocyclic compound, pharmaceutical composition containing same and antitumor application of heterocyclic compound | 和径医药科技（上海）有限公司 | 2023-07-21 | — | — | CN | disclosed |
| CN-109843858-B | Certain chemical entities, compositions and methods | 润新生物公司 | 2023-05-05 | — | — | CN | disclosed |
| CN-114340622-A | Asparagine Endopeptidase (AEP) inhibitors, compositions and uses related thereto | 埃莫里大学 | 2022-04-12 | — | — | CN | disclosed |
| WO-2021121261-A1 | COMPOUND FOR INHIBITING AND INDUCING DEGRADATION OF EGFR KINASE | 北京泰德制药股份有限公司 | 2021-06-24 | — | — | WO | disclosed |
| WO-2021036922-A1 | COMPOUND INHIBITING AND INDUCING DEGRADATION OF EGFR AND ALK | 北京泰德制药股份有限公司 | 2021-03-04 | — | — | WO | disclosed |
| WO-2020200158-A1 | N-HETEROAROMATIC AMIDE DERIVATIVES FOR TREATMENT OF CANCER | 深圳福沃药业有限公司 | 2020-10-08 | — | — | WO | disclosed |
| EP-3705478-A1 | TRIAZINE COMPOUND AND PHARMACEUTICALLY ACCEPTABLE SALT THEREOF | Shenzhen Forward Pharmaceuticals Co., Ltd. (CN) | 2020-09-09 | — | — | EP | disclosed |