Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATF4 | P18848 | 20/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30075998 | 0.87 | ATF4 (0.64) | ATF4 | |
| SCHEMBL19569480 | 0.87 | ATF4 (0.64) | ATF4 | |
| SCHEMBL21116463 | 0.85 | ATF4 (0.61) | ATF4 | |
| SCHEMBL22395386 | 0.85 | ATF4 (0.61) | ATF4 | |
| SCHEMBL20721974 | 0.83 | ATF4 (0.64) | ATF4 | |
| SCHEMBL23610379 | 0.83 | ATF4 (0.52) | ATF4 | |
| SCHEMBL24116743 | 0.83 | ATF4 (0.52) | ATF4 | |
| SCHEMBL22394851 | 0.83 | ATF4 (0.52) | ATF4 | |
| SCHEMBL30682489 | 0.83 | ATF4 (0.52) | ATF4 | |
| SCHEMBL22613942 | 0.83 | ATF4 (0.37) | ATF4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3704096-B1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | CALICO LIFE SCIENCES LLC (US) | 2026-04-22 | — | — | EP | disclosed |
| CN-112204012-B | Modulators of integrated stress pathways | 卡里科生命科学有限责任公司 | 2023-12-26 | — | — | CN | disclosed |
| US-20210205277-A1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | ABBVIE INC. | 2021-07-08 | — | — | US | disclosed |
| EP-3704096-A1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | Calico Life Sciences LLC (US) | 2020-09-09 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210205277-A1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | ATF4, ATF1, DDIT3 | ATF4 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.