SCHEMBL22395294

SCHEMBL22395294

O=C(COc1ccc(Cl)c(F)c1)NC12CCC(C(=O)NCc3ccc(Cl)cc3)(CC1)[C@@H](O)C2

nearest known ligand 0.51

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
▸ ATF4 P18848 20/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19577309 1.00 ATF4 (0.51) ATF4
SCHEMBL30682428 1.00 ATF4 (0.51) ATF4
SCHEMBL22395139 0.95 ATF4 (0.51) ATF4
SCHEMBL19577312 0.95 ATF4 (0.51) ATF4
SCHEMBL19577118 0.93 ATF4 (0.51) ATF4
SCHEMBL22395289 0.93 ATF4 (0.51) ATF4
SCHEMBL19555680 0.93 ATF4 (0.51) ATF4
SCHEMBL19577520 0.93 ATF4 (0.51) ATF4
SCHEMBL24116644 0.92 ATF4 (0.49) ATF4
SCHEMBL19555687 0.92 ATF4 (0.49) ATF4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3704089-A1 MODULATORS OF THE INTEGRATED STRESS PATHWAY Calico Life Sciences LLC (US) 2020-09-09 — — EP disclosed
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